151588-78-2Relevant articles and documents
FLP-Catalyzed Monoselective C-F Functionalization in Polyfluorocarbons at Geminal or Distal Sites
Gupta, Richa,Mandal, Dipendu,Jaiswal, Amit K.,Young, Rowan D.
, p. 1915 - 1920 (2021/04/05)
We report frustrated Lewis pair (FLP)-catalyzed monoselective C-F activation in a range of aliphatic polyfluorocarbons with equivalent geminal and distal C-F positions. This methodology can be applied to aromatic-, ether-, thioether-, and alkyl-supported fluoromethyl groups. We expand the range of FLP base partners that work with monoselective C-F activation to include sulfide. The activated products can be subsequently functionalized via SN2 substitutions, photoredox-alkylations, and Suzuki couplings.
Efficient synthesis of secondary alkyl fluorides via suzuki cross-coupling reaction of 1-halo-1-fluoroalkanes
Jiang, Xiaojian,Sakthivel, Sekarpandi,Kulbitski, Kseniya,Nisnevich, Gennady,Gandelman, Mark
, p. 9548 - 9551 (2014/07/22)
Organofluorine compounds have found extensive applications in various areas of science. Consequently, the development of new efficient and selective methods for their synthesis is an important goal in organic chemistry. Here, we present the first Suzuki c