153-98-0 Usage
Description
Serotonin hydrochloride, also known as 5-hydroxytryptamine hydrochloride, is a monoamine neurotransmitter that plays a crucial role in various biochemical processes within the body. It is derived from tryptophan and is produced in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin hydrochloride is characterized by its white to cream powder appearance and possesses weak acidic properties.
Uses
1. Used in Pharmaceutical Industry:
Serotonin hydrochloride is used as a neurotransmitter for regulating mood, emesis, cognition, and appetite in vivo. It functions as an endogenous serotonin receptor agonist, playing a vital role in the treatment of various disorders associated with low serotonin levels, such as depression, migraines, bipolar disorder, and anxiety.
2. Used in Neurotransmission:
Serotonin hydrochloride is used as a neurotransmitter, facilitating communication between neurons and contributing to the regulation of mood, sleep, vomiting, sexuality, and appetite.
3. Used as a 5-HT Agonist:
Serotonin hydrochloride acts as a 5-HT agonist, interacting with serotonin receptors to modulate various physiological processes and potentially offering therapeutic benefits in the treatment of certain conditions.
4. Used in Research and Development:
Serotonin hydrochloride is utilized in research and development for studying the role of serotonin in the central nervous system and its involvement in various physiological and pathological processes. This knowledge can be applied to develop new therapeutic strategies and drugs targeting serotonin-related disorders.
5. Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, serotonin hydrochloride could potentially be used in drug delivery systems to improve the bioavailability and therapeutic outcomes of medications targeting serotonin-related conditions. This application would require further research and development to optimize the delivery and efficacy of serotonin hydrochloride in such systems.
Biological Activity
Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo .
Biochem/physiol Actions
Neurotransmitter.
Purification Methods
5-HT is purified by recrystallisation from EtOH/Et2O or Et2O to give the hygroscopic salt. Store it in the dark as it is light sensitive. The free base has m 84-86o (from Et2O). The 5-benzyloxy derivative has m 84-86o (from Et2O). [Ek & Witkop J Am Chem Soc 76 5579 1954, Hamlin & Fischer J Am Chem Soc 73 5007 1951.] The picrate 1H2O has m 196-197.5o (dec with sintering at 160-165o) after crystallisation from Et2O. Serotonin is a natural neurotransmitter [Chuang Life Sci 41 1051 1987]. [Beilstein 22/12 V 16.]
Check Digit Verification of cas no
The CAS Registry Mumber 153-98-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 153-98:
(5*1)+(4*5)+(3*3)+(2*9)+(1*8)=60
60 % 10 = 0
So 153-98-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
153-98-0Relevant articles and documents
Method for preparing 5-hydroxytryptamine hydrochloride by utilizing enzymatic fermentation liquor containing 5-hydroxytryptamine
-
Paragraph 0032; 0035-0037; 0038; 0041-0043; 0044; 0047-0049, (2021/02/13)
The invention discloses a method for preparing 5-hydroxytryptamine hydrochloride from 5-hydroxytryptamine-containing enzymatic fermentation liquor, and relates to the technical field of 5-hydroxytryptamine extraction. The method comprises the following steps: concentrating 5-hydroxytryptamine-containing enzymatic fermentation liquor under reduced pressure, mixing the concentrated 5-hydroxytryptamine-containing enzymatic fermentation liquor with an organic solvent, sequentially dropwise adding triethylamine and BOC anhydride at low temperature, heating to 20-25 DEG C after dropwise adding is finished, reacting to obtain an N-BOC-5-hydroxytryptamine reaction solution, adding ethyl acetate, and extracting to obtain an ethyl acetate organic phase; adding ethyl acetate containing hydrochloric acid into the ethyl acetate organic phase for reaction, and performing suction filtration after the reaction is finished to obtain a 5-hydroxytryptamine hydrochloride crude product; and further purifying the obtained 5-hydroxytryptamine hydrochloride crude product to obtain 5-hydroxytryptamine hydrochloride. According t o the invention, high-purity 5-hydroxytryptamine hydrochloride is prepared by optimizing the method for purifying 5-hydroxytryptamine in an enzymatic fermentation liquor, so that the current situation that 5-hydroxytryptamine hydrochloride is difficult to prepare by simply extracting serotonin in the enzymatic fermentation liquor is changed.
