153261-62-2Relevant articles and documents
A new industrial process for 10-methoxyiminostilbene: Key intermediate for the synthesis of oxcarbazepine
Singh, Harnam,Gupta, Nitin,Kumar, Pramod,Dubey, Sushil K.,Sharma, Pawan K.
, p. 870 - 874 (2009)
A new industrial process, involving only two isolation and drying steps, for 10-methoxyiminostilbene (MISB), an advance intermediate of widely prescribed antiepileptic drug, oxcarbazepine, has been developed. A salient feature of this process is the novel use of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) to afford bro-mohydrin methyl ether from N-acetyliminostilbene. The byproducts of this process namely acetic acid, 5,5-dimethylhydantoin and Et3N HBr are recyclable as well as nontoxic This process is amenable for the large-scale production of MISB.
New synthesis of 10-alkoxy-5-H-dibenz[b,f]azepines
Haasz,Galamb
, p. 683 - 687 (1994)
The reaction of 5-acetyl-5H-dibenz[b,f]azepines with sodium-hypochlorite led to the 5-acetyl-10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepine (1). The lithium iodide induced rearrangement of 1 gave the keton 2 which was reacted with trialkyl-orthoformates leading to the vinyl ethers 3a,b.
