153333-52-9

Basic information

• Product Name: 1-(2-iodoethyl)-2-(iodomethyl)benzene
• Synonyms: 1-(2-iodoethyl)-2-(iodomethyl)benzene
• CAS NO: 153333-52-9
• Molecular Weight: 371.987
• Mol File: 153333-52-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-iodoethyl)-2-(iodomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-iodoethyl)-2-(iodomethyl)benzene(153333-52-9)
• EPA Substance Registry System: 1-(2-iodoethyl)-2-(iodomethyl)benzene(153333-52-9)

Safety Data

• Hazardous Substances Data: 153333-52-9(Hazardous Substances Data)

Upstream product

• 4385-35-7 isochroman-3-one 
• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 493-05-0 isochromane 

Downstream Products

• 78317-78-9 2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1057279-93-2 C₁₅H₁₄BrN 
• 1057279-94-3 C₁₅H₁₄IN 
• 1057279-03-4 C₁₅H₁₄IN 
• 1057280-08-6 C₁₆H₁₄F₃N 
• 78317-81-4 2-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1057277-76-5 2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline 
• 140381-66-4 1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline 
• 41852-30-6 2-(4-nitrophenyl)-3,4-dihydroisoquinolin-2-ium bromide 
• 97834-61-2 2-(2-methylphenyl)-3,4-dihydroisoquinolin-2-ium bromide 
• 1234178-53-0 2-(3-methylphenyl)-3,4-dihydroisoquinolin-2-ium bromide 
• 41852-28-2 N-p-Tolyl-3,4-dihydro-isochinoliniumbromid 
• 1391848-54-6 C₁₅H₁₄NO⁽¹⁺⁾*Br^(1-) 
• 1234178-62-1 2-(4-hydroxylphenyl)-3,4-dihydroisoquinolin-2-ium bromide 

Relevant articles and documents

Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles

A general phase-transfer-catalyzed asymmetric (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles with alkyl dihalides that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously inacc

2-(substituted phenyl)-3,4-dihydroisoquinolin-2-iums as novel antifungal lead compounds: Biological evaluation and structure-activity relationships

The title compounds are a class of structurally simple analogues of quaternary benzo[c]phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N-phenylring were evaluated for bioactivity against seven phytopathogenic fungi using the mycelial growth rate method and their SAR discussed. Almost all the compounds showed definite activities in vitro against each of the test fungi at 50 μg/mL and a broad antifungal spectrum. In most cases, the mono-halogenated compounds 2-12 exhibited excellentactivities superior to the QBAs sanguinarine and chelerythrine. Compound 8 possessed the strongest activities on each of the fungi with EC50 values of 8.88-19.88 μg/mL and a significant concentration-dependent relationship. The SAR is as follows: the N-phenyl group is a high sensitive structural moiety for the activity and the characteristics and position of substituents intensively influence the activity. Generally, electron-withdrawing substituents remarkably enhance the activity while electron-donating substituents cause a decrease of the activity. In most cases, ortha- and para-halogenated isomers were more active than the corresponding m-halogenated isomers. Thus, the title compounds emerged as promising lead compounds for the development of novel biomimetic antifungal agrochemicals. Compounds 8 and 2 should have great potential as new broad spectrum antifungal agents for plant protection.