1533519-84-4 Usage
Description
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is an organic compound characterized by its off-white powder form. It is a derivative of the 1,2,4-triazole family, featuring a cyclopropylnaphthalenyl group attached to the 4th position and a thione group at the 5th position. 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is known for its potential applications in various fields due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione is used as a reagent for the discovery of Lesinurad, a HEK293 cell-based inhibitor. Lesinurad is a medication used to treat hyperuricemia, a condition characterized by high levels of uric acid in the blood, which can lead to gout and kidney stones. The compound plays a crucial role in the development and synthesis of Lesinurad, contributing to its therapeutic effects and potential benefits for patients suffering from hyperuricemia.
Used in Chemical Research:
In addition to its application in the pharmaceutical industry, 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione may also be utilized in chemical research and development. Its unique structure and properties make it a valuable compound for exploring new chemical reactions, synthesis pathways, and potential applications in various fields, including materials science, agrochemistry, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 1533519-84-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,3,5,1 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1533519-84:
(9*1)+(8*5)+(7*3)+(6*3)+(5*5)+(4*1)+(3*9)+(2*8)+(1*4)=164
164 % 10 = 4
So 1533519-84-4 is a valid CAS Registry Number.
1533519-84-4Relevant articles and documents
A process for the preparation of intermediates to si Lei (by machine translation)
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, (2017/06/02)
The invention discloses a compound of formula (I) the method for the preparation of intermediates shows Si Lei. The method can directly introduce triazazole functional group, the reaction yield is up to 96.30%, sulfur generation and avoid the use of toxic reagent such as phosgene. Furthermore, the synthetic route of this invention does not need to ring closing reaction step, a total of six-step reaction of the final product can be obtained, it is simple and convenient to prepare, low cost, is suitable for industrial production. (by machine translation)
THIO-1,2,4-TRIAZOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME
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, (2015/01/09)
Provided is a process for preparing a compound shown as formula (I), comprising a step of contacting a compound shown as formula (II) or a salt thereof with a brominating agent, wherein R1is OR2 or NR3R4; R2 is C1-C6 alkyl or phenyl; each R3, R4 is independently H, C1-C6 alkyl or cycloalkyl, wherein C1-C6 alkyl, cycloalkyl, or phenyl is optionally further substituted by F, Cl, Br, CH3 or CF3. A process for preparing a compound shown as formula (II), a process for preparing a compound shown as formula (V), a process for preparing a compound shown as formula (III), and an intermediate compound as shown as formula (IIa) or formula (Ib) are also provided.