154023-64-0

Basic information

• Product Name: Benzoic acid, 3,3'-methylenebis[5-chloro-6-methoxy-, dimethyl ester
• CAS NO: 154023-64-0
• Molecular Formula: C19H18Cl2O6
• Molecular Weight: 413.254
• Mol File: 154023-64-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-methoxy-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,3'-methylenebis[5-chloro-6-methoxy-, dimethyl ester(154023-64-0)
• EPA Substance Registry System: Benzoic acid, 3,3'-methylenebis[5-chloro-6-methoxy-, dimethyl ester(154023-64-0)

Safety Data

• Hazardous Substances Data: 154023-64-0(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 397843-09-3 3,3'-dicarbomethoxy-5,5'-dichloro-4,4'-dihydroxydiphenylmethane 
• 1829-32-9 3-Chloro-2-hydroxybenzoic acid 
• 128626-47-1 3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 

Downstream Products

• 183487-85-6 tetra(3-chloro-4-methoxy-5-methoxycarbonylphenyl)ethylene 
• 154023-65-1 3,3'-dichloro-4,4'-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 

Relevant articles and documents

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

The alkenyldiarylmethanes (ADAMs) are currently being investigated as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS. During the course of these studies, a number of ADAM analog

HETEROBIFUNCTIONAL COMPOUNDS FOR SELECTIN INHIBITION

Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

Design, Synthesis, and Biological Evaluation of Cosalane, a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus Reproduction

Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized from commercially available starting materials by a convergent route.Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a variety of laboratory, drug-resistant, and clinical HIV-1 isolates, HIV-2, and Rauscher murine leukemia virus.The cytotoxicity of cosalane is relatively low as reflected by an in vitro therapeutic index of > 100.Although cosalane inhibits HIV-1 reverse transcriptase and protease, time of addition experiments indicate that it prevents the cytopathic effect of HIV by acting earlier than reverse transcription in the viral replication cycle.The available evidence indicates that the primary mechanism of action of cosalane involves inhibition of gp 120-CD4 binding as well as inhibition of a postattachment event prior to reverse transcription.