154023-65-1Relevant articles and documents
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors
Cullen, Matthew D.,Cheung, York-Fong,Houslay, Miles D.,Hartman, Tracy L.,Watson, Karen M.,Buckheit Jr., Robert W.,Pannecouque, Christophe,De Clercq, Erik,Cushman, Mark
, p. 1530 - 1533 (2008/09/19)
The alkenyldiarylmethanes (ADAMs) are currently being investigated as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS. During the course of these studies, a number of ADAM analog
HETEROBIFUNCTIONAL COMPOUNDS FOR SELECTIN INHIBITION
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Page/Page column 26-27, (2008/06/13)
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
Studies directed toward a more potent cosalane pharmacophore: Synthesis of a substituted tetraphenylethylene which inhibits the cytopathic effect of HIV-1
Keyes, Robert F.,Cushman, Mark
, p. 372 - 376 (2007/10/03)
Tetra(3-carboxy-5-chloro-4-hydroxyphenyl)ethylene (6) was prepared by a modified McMurry coupling of 3,3′-dichloro-5,5′-di(methoxycarbonyl)-4,4′- dimethoxybenzophenone (9) in the presence of zinc and titanium tetrachloride in refluxing tetrahydrofuran, fo