154170-22-6Relevant articles and documents
Asymmetric bromine-lithium exchange: Application toward the synthesis of natural product
Graff, Julien,Debande, Thibaut,Praz, Jezabel,Guenee, Laure,Alexakis, Alexandre
, p. 4270 - 4273 (2013)
Asymmetric bromine-lithium exchange has been successfully employed to synthesize bicoumarin chiral building blocks of (+)-isokotanin A and (-)-kotanin in good yields and with an excellent level of enantioselectivity. This is the first reported example of formal syntheses, using this direct methodology, leading to the single (M)-atropoisomer of (+)-isokotanin A and (-)-kotanin building blocks, without any resolution step.