154318-70-4

Basic information

• Product Name: {2-[1-(4-Chloro-phenyl)-vinyloxy]-ethyl}-dimethyl-amine
• Synonyms: {2-[1-(4-Chloro-phenyl)-vinyloxy]-ethyl}-dimethyl-amine
• CAS NO: 154318-70-4
• Molecular Weight: 225.718
• Mol File: 154318-70-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {2-[1-(4-Chloro-phenyl)-vinyloxy]-ethyl}-dimethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[1-(4-Chloro-phenyl)-vinyloxy]-ethyl}-dimethyl-amine(154318-70-4)
• EPA Substance Registry System: {2-[1-(4-Chloro-phenyl)-vinyloxy]-ethyl}-dimethyl-amine(154318-70-4)

Safety Data

• Hazardous Substances Data: 154318-70-4(Hazardous Substances Data)

Upstream product

• 3622-76-2 (2-ethenyloxyethyl)dimethylamine 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 697747-16-3 N,N-dimethyl-2-[1,2-di(p-chlorophenyl)ethenyloxy]ethanamine 
• 1026681-58-2 {2-[1-(4-chloro-phenyl)-2,2-diphenyl-vinyloxy]-ethyl}-dimethyl-amine 
• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 63704-23-4 α,α-diphenylchloroacetophenone 

Relevant articles and documents

Highly regioselective, sequential, and multiple palladium-catalyzed arylations of vinyl ethers carrying a coordinating auxiliary: An example of a heck triarylation process

This article describes the development of new auxiliary-accelerated Heck multiarylations by intramolecular presentation of the oxidative addition complex. The introduction of a specific, palladium-coordinating dimethylamino group allows for the desired chelation-accelerated and chelation-controlled tri- and diarylation reactions. We report (a) the first example of a Heck triarylation process, (b) highly selective palladium-catalyzed diarylations of alkyl vinyl ethers, and (c) a very rapid two-phase protocol for the microwave-assisted hydrolysis of amino-substituted, arylated vinyl ethers constituting an entry to diarylated ethanals and substituted desoxybenzoins. X-ray structures and product patterns support the suggested substrate-controlled Heck reaction pathway. The catalyst-directing alkyl dimethylamino functionality was rapidly (1-2 min) and efficiently released by microwave hydrolysis after Heck multiarylation reactions. The liberated aromatic carbonyl compounds were thereafter isolated and fully characterized.