63704-23-4Relevant articles and documents
One-pot synthesis of α,α-disubstituted Aryl-1-ethanones via the Wittig-Horner reaction
Yang, Yunxia,Wang, Le,Chen, Yuan,Dai, Yiru,Sun, Zhihua
, p. 121 - 126 (2018/01/04)
A one-pot methodology for the synthesis of α,α-disubstituted aryl-1-ethanones via the Wittig-Horner reaction has been developed and described in this manuscript. Both aryl/alkyl and dialkyl α-branched arylethanone were obtained in high yields (up to 96%) without the use of any metal catalysts. A total of 14 α,α-disubstituted arylethanone derivatives were synthesized based on this simple method that easily converts the carbonyl carbon (sp2) into the sp3 carbon. This versatile method is expected to further promote the use of substituted ketones as synthetic building blocks to construct a variety of α-branched aryl ketones.
N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides
Padmanaban, Mohan,Biju, Akkattu T.,Glorius, Frank
supporting information; experimental part, p. 98 - 101 (2011/03/19)
N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.
Low-valent titanium promoted self-coupling of N-acylbenzotriazoles and their cross-coupling with diarylketones
Wang, Xiaoxia,Zhang, Yongmin
, p. 2627 - 2634 (2007/10/03)
The self-coupling reaction of N-acylbenzotriazoles and their cross-coupling with diarylketones promoted by Sm/TiCl4 system were investigated. Self-coupling reaction could afford α-diketones or benzoins in moderate yields, while the cross-coupli
