154371-07-0

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine
• CAS NO: 154371-07-0
• Molecular Weight: 542.588
• Mol File: 154371-07-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine(154371-07-0)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-3'-ketothymidine(154371-07-0)

Safety Data

• Hazardous Substances Data: 154371-07-0(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-89-5 thymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 154371-09-2 1-(2,3-dideoxy-5-O-(4,4'-dimethoxytrityl)-3-C-hydroxymethyl-β-D-threo-pentofuranosyl)thymine 
• 154468-75-4 1-[(2R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 154468-74-3 5'-O-(4,4'-dimethoxytrityl)-3'-C-(hydroxymethyl)thymidine 
• 511545-98-5 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterothymidine 
• 186963-82-6 1-{(2R,4R,5R)-4-(Benzenesulfonyl-difluoro-methyl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 154371-08-1 3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-C-methylenethymidine 

Relevant articles and documents

A deuterated nucleoside phosphoramidite monomer synthesis method

The invention discloses a synthesis method of a deuterium-substituted nucleoside phosphoramidite monomer. According to the technical scheme, the synthesis method of the deuterium-substituted nucleoside phosphoramidite monomer comprises the following steps

Stereospecific syntheses of 3'-deuterated pyrimidine nucleosides and their site-specific incorporation into DNA.

[reaction: see text] 2'-Deoxy-3'-deutero pyrimidines have been synthesized in high yields and incorporated into deoxyoligonucleotides using standard phosphoramidite chemistry. A key synthetic step is a stereospecific reduction of 3'-keto nucleosides using sodium triacetoxyborodeuteride to give 3'-deuterated thymidine and 2'-deoxy uridine nucleosides. Conversion of the corresponding phorphoramidites 7a and 7b to 4-triazolo derivatives has, for the first time, enabled incorporation of 2'-deoxy-3'-deutero cytidine and 2'-deoxy-3'-deutero-5-methyl cytidine into oligonucleotides.

Synthesis of 3′-C-(Hydroxymethyl)thymidine: Introduction of a novel class of deoxynucleosides and oligodeoxynucleotides

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