186963-82-6Relevant articles and documents
Synthesis of 3'-difluoromethylene-3'-deoxythymidine and some derivatives
Serafinowski, Pawel J.,Barnes, Colin L.
, p. 225 - 228 (1997)
Ultrasound-assisted reaction of the 3'-oxo derivative of thymidine (1) with bromodifluoromethyl[tris(dimethylamino)phosphonium] bromide (8) and zinc, gives the corresponding 3'-difluoromethylene nucleoside 5. Subsequent removal of the dimethoxytrityl group provides hitherto unreported 3'-difluoromethylene-3'-deoxythymidine (6), a new analogue of AZT.