154377-49-8

Basic information

• Product Name: (R)-1-(2-chlorophenyl)-1-(trichlorosilyl)ethane
• Synonyms: (R)-1-(2-chlorophenyl)-1-(trichlorosilyl)ethane
• CAS NO: 154377-49-8
• Molecular Weight: 274.049
• Mol File: 154377-49-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-1-(2-chlorophenyl)-1-(trichlorosilyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2-chlorophenyl)-1-(trichlorosilyl)ethane(154377-49-8)
• EPA Substance Registry System: (R)-1-(2-chlorophenyl)-1-(trichlorosilyl)ethane(154377-49-8)

Safety Data

• Hazardous Substances Data: 154377-49-8(Hazardous Substances Data)

Upstream product

• 2039-87-4 2-chlorostyrene 

Downstream Products

• 13524-04-4 (R)-1-(o-chlorophenyl)ethanol 

Relevant articles and documents

Highly enantioselective hydrosilylation of aromatic alkenes

Currently, the most effective and economic way to convert an alkene into an optically active alcohol is the two-step sequence: hydrosilylation/oxidation. Much work has been devoted to elucidating effective catalysts for this process, but hitherto only one effective and highly stereoselective process has been available. Herein we present a novel catalytic system for the asymmetric hydrosilylation of aromatic alkenes, giving the products in high yields and with the highest enantioselectivity (up to 99% ee) ever observed for this reaction. The reaction works efficiently for a variety of substituted aromatic alkenes, giving access after Tamao oxidation to almost optically pure benzylic alcohols in high yields. Copyright

Asymmetric palladium-catalyzed hydrosilylation of styrenes using efficient chiral spiro phosphoramidite ligands

Asymmetric hydrosilylation of styrene derivatives with trichlorosilane in the presence of palladium complexes of chiral spiro phosphoramidites provided 1-aryl-1-silylalkanes as single regioisomers in high yields, which have been oxidized with hydrogen peroxide to give the corresponding chiral alcohols in up to 99.1% ee.

Regio- and Enantioselective Hydrosilylation of 1-Arylalkenes by Use of Palladium-MOP Catalyst

Hydrosilylation of styrenes bearing β-substituents with trichlorosilane was catalyzed by a palladium complex (0.1 mol percent) coordinated with (R)-2-methoxy-2'-diphenylphosphino-1,1'-binaphthyl ((R)-MeO-MOP) to give high yields of optically active 1-aryl-1-silylalkanes (80-85percent ee) as single regioisomers.The resulting silanes were readily converted into the corresponding optically active alcohols (80-99percent yield).