154420-79-8

Basic information

• Product Name: (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril
• CAS NO: 154420-79-8
• Molecular Weight: 237.304
• Mol File: 154420-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril(154420-79-8)
• EPA Substance Registry System: (+/-)-4-Methyl-2-(1-phenylethylamino)nicotinonitril(154420-79-8)

Safety Data

• Hazardous Substances Data: 154420-79-8(Hazardous Substances Data)

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 154420-75-4 (E)-(+/-)-3-Amino-3-(1-phenylethylamino)acrylnitril 

Downstream Products

• 71493-76-0 2-amino-4-methylpyridine-3-carbonitrile 

Relevant articles and documents

Substituted 2-aminonicotinonitriles

Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.