71493-76-0Relevant articles and documents
Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction
Chan, David C. M.,Rosowsky, Andre
, p. 1364 - 1368 (2007/10/03)
(Chemical Equation Presented) A regiospecific and convergent route the lipophilic antifolate piritrexim (PTX) is described in which a key step is a Pd(0)-catalyzed cross-coupling reaction between 2-amino-3-cyano-4-methyl-5- bromopyridine and 2,5-dimethoxy
The reaction of some brominated aminopicolines with acetic anhydride and with copper(I) cyanide
Dunn,Norrie
, p. 663 - 666 (2007/10/03)
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Substituted 2-aminonicotinonitriles
Troschutz,Dennstedt
, p. 85 - 89 (2007/10/02)
Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.