15446-43-2

Basic information

• Product Name: NEAMINE HYDROCHLORIDE
• Synonyms: NEAMINE HYDROCHLORIDE;2-Deoxy-4-O-(2,6-diaMino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptaMine Hydrochloride;NeoMycin A Tetrahydrochloride
• CAS NO: 15446-43-2
• Molecular Formula: C₁₂H₂₆N₄O₆*4ClH
• Molecular Weight: 468.203
• Product Categories: Oligosaccharides
• Mol File: 15446-43-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 289 °C (decomp)
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• CAS DataBase Reference: NEAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NEAMINE HYDROCHLORIDE(15446-43-2)
• EPA Substance Registry System: NEAMINE HYDROCHLORIDE(15446-43-2)

Safety Data

• Hazardous Substances Data: 15446-43-2(Hazardous Substances Data)

Usage

Description

Neamine Hydrochloride, a core structure of aminoglycoside antibiotics, is a compound with significant antibacterial properties. It plays a crucial role in the development of various pharmaceutical agents due to its ability to combat bacterial infections.

Uses

Used in Pharmaceutical Industry:
Neamine Hydrochloride is used as a core structure for the synthesis of aminoglycoside antibiotics, specifically disaccharide neamine derivatives. These derivatives serve as potent antibacterial agents, effective against a wide range of bacterial infections. The compound's ability to inhibit bacterial growth and disrupt essential cellular processes makes it a valuable asset in the fight against antibiotic-resistant strains.

Upstream product

• 119-04-0 neomycin B 
• 25389-98-4 neomycin B sulphate 
• 67-56-1 methanol 

Downstream Products

• 671809-10-2 1,3,2′,6′-tetraazidoneamine 
• 61066-03-3 1,2',3,6'-tetrakis-N-(trifluoroacetyl)neamine 
• 54230-72-7 {(1R,2S,3R,4R,5S)-5-tert-Butoxycarbonylamino-4-[(2R,3R,4R,5S,6R)-3-tert-butoxycarbonylamino-6-(tert-butoxycarbonylamino-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yloxy]-2,3-dihydroxy-cyclohexyl}-carbamic acid tert-butyl ester 
• 77967-96-5 6'-N-benzyloxycarbonylneamine 
• 937021-95-9 (2R,3R,4R,5R,6R)-3-azido-6-(azidomethyl)-4,5-bis(benzyloxy)-2-(((1R,2R,3S,4R,6S)-4,6-diazido-2,3-bis(benzyloxy)cyclohexyl)oxy)tetrahydro-2H-pyran 
• 937021-97-1 6-O-acetyl-1,3,2',6'-tetraazido-5-O-methoxymethylneamine 
• 937021-98-2 C₁₆H₂₂O₈N₁₂ 
• 937021-96-0 1,3,2',6'-tetraazido-5-O-methoxymethyl-6,3',4'-tri-O-acetylneamine 
• 182554-04-7 1,3,2′,6′-tetraazido-6,3′,4′-tri-O-acetylneamine 
• 182554-06-9 5,6,3',4'-tetra-O-acetyl-1,3,2',6'-tetrazidoneamine 
• 688744-66-3 1,3,2',6'-tetraazido-3',4'-di-O-acetylneamine 
• 688744-70-9 6-O-(4''-azido-2'',3''-di-O-benzyl-4'',6''-dideoxy-α-D-galactopyranosyl)-1,3,2',6'-tetraazidoneamine 
• 688744-68-5 6-O-(6''-azido-2'',3''-di-O-benzyl-6''-deoxy-α-D-galactopyranosyl)-1,3,2',6'-tetraazidoneamine 
• 688744-67-4 6-O-(4'',6''-diazido-2'',3''-di-O-benzyl-4'',6''-dideoxy-α-D-glucopyranosyl)-1,3,2',6'-tetraazidoneamine 

Relevant articles and documents

Aminoglycoside antibiotic derivatives: Preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity

Aminoglycoside antibiotic derivatives such as neamine, methyl neobiosaminide B, 2-deoxystreptamine, tetra-azidoneamine, tetra-N-acetylneamine, tetra-N-carboxy-benzylneamine, tetra-N-carboxy-methylneamine and tetra-p-methoxy-benzyliminoneamine were prepare

Designed spiro-bicyclic analogues targeting the ribosomal decoding center

The bacterial ribosome represents the confirmed biological target for many known antibiotics that interfere with bacterial protein synthesis. Aminoglycosides represent a lead paradigm in RNA molecular recognition and constitute ideal starting points for t

Synthesis of aminoglycoside-modified oligonucleotides

(matrix presented) To study the structural requirements of aminoglycoside binding to nucleic acids, compound 1 - an analogue of the naturally occurring nucleoside J - was synthesized. When incorporated into oligodeoxynucleotides, 1 leads to thermal stabil