15467-31-9

Basic information

• Product Name: 2-(1H-indol-3-yl)-2-methylpropan-1-amine
• Synonyms: 2-(1H-indol-3-yl)-2-methylpropan-1-amine;1H-Indole-3-ethanaMine, b,b-diMethyl-;3-(2-Amino-tert-butyl)indole;beta,beta-Dimethyltryptamine
• CAS NO: 15467-31-9
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.272
• Mol File: 15467-31-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 347.3°Cat760mmHg
• Flash Point: 190.7°C
• Appearance: /
• Density: 1.093
• Vapor Pressure: 5.45E-05mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(1H-indol-3-yl)-2-methylpropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-indol-3-yl)-2-methylpropan-1-amine(15467-31-9)
• EPA Substance Registry System: 2-(1H-indol-3-yl)-2-methylpropan-1-amine(15467-31-9)

Safety Data

• Hazardous Substances Data: 15467-31-9(Hazardous Substances Data)

Usage

General Description

The chemical "2-(1H-indol-3-yl)-2-methylpropan-1-amine" is a derivative of the amino acid tryptophan and is also known as Alpha-methyltryptamine (AMT). It is a psychoactive drug that acts as a stimulant and hallucinogen, producing effects similar to those of amphetamine and LSD. AMT has been used recreationally for its euphoric and psychedelic effects, but it can also have harmful side effects such as increased heart rate, agitation, and potential for overdose. It is considered a controlled substance in many countries due to its potential for abuse and addiction, and its use is illegal in many jurisdictions.

InChI:InChI=1/C12H16N2/c1-12(2,8-13)10-7-14-11-6-4-3-5-9(10)11/h3-7,14H,8,13H2,1-2H3

Upstream product

• 2770-92-5 2-indol-3-yl-2-methyl-propionic acid 
• 23078-29-7 2-(1H-indol-3-yl)-2-methylpropanenitrile 
• 380626-46-0 3-(2-cyanopropane-2-yl)-1H-indol-1-carboxylic acid tert-butyl ester 

Downstream Products

• 942145-77-9 isopropyl 1,1-dimethyl-1,2,3,6-tetrahydro-azepino[4,5-b]indole-5-carboxylate 
• 629662-20-0 ethyl 1,1-dimethyl-1,2,3,6-tetrahydro-azepino[4,5-b]indole-5-carboxylate 

Relevant articles and documents

Benzylamine derivatives and its application on the medicament

The invention provides novel benzylamine derivatives or stereoisomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or pro-drugs thereof for treating Alzheimer diseases. The invention also provides a medicine composition containing a compound provided by the invention and a method for treating the Alzheimer diseases by using the compound or the medicine composition of the compound provided by the invention.

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)

Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC50 = 4 nM, Eff = 149%). Oral administration of 6m to LDLR-/- mice results in lowering of cholesterol and triglycerides. Chronic administration in an atherosclerosis model results in significant reduction in aortic arch lesions.

-3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Y are as defined herein, or a tautomer, prodrug, solvate, or sal