15500-74-0

Basic information

• Product Name: Benzonitrile,4-chloro-N-oxide
• Synonyms: Benzonitrile,4-chloro-N-oxide
• CAS NO: 15500-74-0
• Molecular Formula: C₇H₄ClNO
• Molecular Weight: 153.56576
• Mol File: 15500-74-0.mol
• Article Data: 31

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.2g/cm³
• Refractive Index: 1.55
• CAS DataBase Reference: Benzonitrile,4-chloro-N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile,4-chloro-N-oxide(15500-74-0)
• EPA Substance Registry System: Benzonitrile,4-chloro-N-oxide(15500-74-0)

Safety Data

• Hazardous Substances Data: 15500-74-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4ClNO/c8-7-3-1-6(2-4-7)5-9-10/h1-4H

Upstream product

• 33341-64-9 N-Chloro-4-chlorobenzamide 
• 29559-24-8 4-chlorophenylnitromethane 
• 133362-01-3 4-chloro-α-nitro-benzaldehyde seqtrans-oxime 
• 3848-36-0 4-chlorobenzaldoxime 
• 74903-80-3 (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 3717-24-6 4-chlorobenzaldehyde oxime 

Downstream Products

• 10284-99-8 1-[3-(4-chlorophenyl)-isoxazol-5-yl]piperidine 
• 5301-02-0 5-(chloromethyl)-3-(4-chlorophenyl)isoxazole 
• 3191-92-2 4-[3-(4-chloro-phenyl)-5-isopropyl-4,5-dihydro-isoxazol-5-yl]-morpholine 
• 10285-02-6 1-[3-(4-chlorophenyl)-isoxazol-5-yl]morpholine 
• 21614-47-1 3-(4-chlorophenyl)-5-methyl-1,2,4-oxadiazole 
• 21614-50-6 3-(4-chloro-phenyl)-5-phenethyl-[1,2,4]oxadiazole 
• 21614-48-2 3-(4-chloro-phenyl)-5-(2-ethoxy-ethyl)-[1,2,4]oxadiazole 
• 71637-71-3 3-(4-chloro-phenyl)-3a,5-diethyl-6,6a-diphenyl-(3ar,6ac)-3a,6a-dihydro-cyclopenta[d]isoxazol-4-one 
• 71637-79-1 3-(4-chloro-phenyl)-3a-ethyl-5,6,6a-triphenyl-(3ar,6ac)-3a,6a-dihydro-cyclopenta[d]isoxazol-4-one 
• 10284-98-7 1-[3-(4-chlorophenyl)-isoxazol-5-yl]-4-methylpiperazine 
• 29363-96-0 5-butyl-3-(4-chlorophenyl)isoxazole 
• 66168-72-7 3-(4-chloro-phenyl)-3a,5,6,6a-tetraphenyl-(3ar,6ac)-3a,6a-dihydro-cyclopenta[d]isoxazol-4-one 
• 13273-57-9 3-(4-chlorophenyl)-5-phenyl-1,2,4-oxadiazole 
• 21614-49-3 5-benzyl-3-(4-chloro-phenyl)-[1,2,4]oxadiazole 

Relevant articles and documents

Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride

A regioselective metal-free preparation of 4-fluorosulfonyl 1,2,3-triazoles from organic azides and a hitherto underexplored bromovinylsulfonyl fluoride building block is described. This reaction is very general and was extended to the synthesis of variou

Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors

α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.

One-pot Synthesis of Some Novel Xanthine Derived Isoxazoles as Potent Antibacterial Agents

In search of better antibacterial agents, a series of novel xanthine derived 3,5-disubstituted isoxazole derivatives were synthesized (3a-3j) in one-pot using 8-chloro-1,3-dimethyl-7-(prop-2-yn-1-yl)-1H-purine-2,6(3H,7H)-dione and aromatic aldehydes and f

Cu(I)-Catalysis of One-Pot Synthesis of Some Novel Regioselective Isoxazole-Benzimidazole Hybrids and Their In Vitro Anti-Cancer Evaluation

Regioselective synthesis of some novel isoxazole-benzimidazole hybrids in high yields via Cu(I)-catalyzed tandem one-pot reaction of aromatic aldehydes with 1-prop-2-ynylbenzimidazole is developed. Structures of the synthesized compounds are confirmed by