74903-80-3

Basic information

• Product Name: (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride
• Synonyms: (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride
• CAS NO: 74903-80-3
• Molecular Weight: 190.029
• Mol File: 74903-80-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride(74903-80-3)
• EPA Substance Registry System: (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride(74903-80-3)

Safety Data

• Hazardous Substances Data: 74903-80-3(Hazardous Substances Data)

Usage

Description

(Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride, with the molecular formula C7H5Cl2NO2, is a chemical compound derived from benzenecarboximidoyl chloride. It features a chlorine atom and a hydroxy group attached to the benzene ring, which contributes to its chemical reactivity and potential for creating new compounds with useful properties.

Uses

Used in Pharmaceutical Industry:
(Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride is utilized as a key intermediate in the creation of different agrochemicals, such as pesticides and herbicides, due to its chemical reactivity and versatility.
Used in Research and Development:
(Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride is also used in research for its potential applications in medicinal chemistry. Its unique properties make it a valuable compound for exploring new avenues in drug discovery and development.
Used in Organic Synthesis:
As a versatile intermediate, (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride is employed in organic synthesis to produce a wide range of organic compounds with various applications across different industries. Its chemical reactivity and potential for creating new compounds with useful properties make it a valuable asset in the field of organic chemistry.

Upstream product

• 3717-24-6 4-chlorobenzaldehyde oxime 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 132906-67-3 (3aR,9aS)-3-(4-Chloro-phenyl)-9-methyl-3a,4,9,9a-tetrahydro-isoxazolo[5,4-b]quinoline-4-carbonitrile 
• 161064-10-4 3-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-isoxazole 
• 888-71-1 3,5-diphenyl-1,2,4-oxadiazole 
• 58696-04-1 12-(4-chloro-benzoyl)-9,10-dimethyl-9,10-dihydro-10,9-oxaazaethano-anthracene 
• 61713-85-7 3,5-bis(p-chlorophenyl)-1,2,4-oxadiazole 4-oxide 
• 188118-34-5 3-(4-Chloro-phenyl)-5-phenyl-[1,2,4]oxadiazole 4-oxide 
• 7541-06-2 (4-chlorophenyl)<(Z)-hydroxyimino>acetonitrile 
• 1312032-56-6 (Z)-N-tert-butyl-2-(4-chlorophenyl)-2-(cinnamoyloxyimino)acetamide 
• 26218-72-4 3,4-bis-(4-chloro-phenyl)-furazan 2-oxide 

Relevant articles and documents

Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters

Redox-active esters (RAEs) as alkyl radical precursors have been extensively developed for C?C bond formations. However, the analogous transformations of fluoroalkyl radicals from the corresponding acid or ester precursors remain challenging because of the high oxidation potential of the fluoroalkyl carboxylate anions. The newly developed N-hydroxybenzimidoylchloride (NHBC) ester provides a general leaving group assisted strategy to generate a portfolio of fluoroalkyl radicals, and can be successfully applied in photoinduced decarboxylative hydrofluoroalkylation and heteroarylation of unactivated olefins. In addition, DFT calculations revealed that the NHBC ester proceeds by the fluorocarbon radical pathway, whereas other well-known RAEs proceed by the nitrogen radical pathway.

HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

Diastereoselective cycloadditions of a soluble polymer-supported substituted allyl alcohol derived from Baylis-Hillman reaction with nitrile oxides

A diastereoselective cycloaddition of a soluble polymer-supported Baylis-Hillman adduct with nitrile oxides is described. The reaction has shown to proceed with moderate diastereoselectivity, favoring the syn isomer of the resulting 3,5-substituted isoxazolines. The stereochemistry of the products has been assigned using 1H NMR studies. The structure of one of the diastereomers has been determined by single-crystal X-ray crystallographic analysis.