155371-59-8

Basic information

• Product Name: PACLITAXEL SIDE CHAIN 2
• Synonyms: PACLITAXEL SIDE CHAIN 2;PACLITAXEL SIDE CHIAN 2;(3R,4S)-1-Benzoyl-4-phenyl-3-((triisopropylsilyl)oxy)azetidin-2-one
• CAS NO: 155371-59-8
• Molecular Formula: C₂₅H₃₃NO₃Si
• Molecular Weight: 423.626
• Mol File: 155371-59-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: PACLITAXEL SIDE CHAIN 2(CAS DataBase Reference)
• NIST Chemistry Reference: PACLITAXEL SIDE CHAIN 2(155371-59-8)
• EPA Substance Registry System: PACLITAXEL SIDE CHAIN 2(155371-59-8)

Safety Data

• Hazardous Substances Data: 155371-59-8(Hazardous Substances Data)

Usage

General Description

PACLITAXEL SIDE CHAIN 2 is a synthetic organic compound that is used as a building block in the synthesis of paclitaxel, a chemotherapy medication used to treat various types of cancer. This chemical compound plays a crucial role in the production of paclitaxel, as it is used to modify and enhance the drug's effectiveness and target specific cancer cells. By incorporating this side chain into the structure of paclitaxel, the drug's pharmacological properties are optimized, ultimately leading to improved treatment outcomes for cancer patients. Therefore, PACLITAXEL SIDE CHAIN 2 is an essential component in the production of paclitaxel, a widely used and effective cancer treatment medication.

Upstream product

• 98-88-4 benzoyl chloride 
• 132127-31-2 (3R,4S)-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 100-52-7 benzaldehyde 
• 144465-78-1 1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone 
• 146924-94-9 (3R,4S)-(+)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 94612-33-6 1-(4-methoxyphenyl)-4-phenylazetidine-2,3-dione 
• 194234-97-4 3-Hydroxy-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one 
• 186613-02-5 cis-1-p-methoxyphenyl-3-acetoxy-4-phenylazetidin-2-one 

Downstream Products

• 202996-23-4 C₅₉H₈₂N₂O₁₂Si₂ 
• 709633-33-0 C₅₅H₆₈ClNO₁₄Si 
• 709633-32-9 C₅₅H₆₈N₄O₁₄Si 
• 709633-39-6 C₅₆H₇₀ClNO₁₄Si 
• 709633-37-4 C₅₈H₆₆ClNO₁₄Si 
• 709633-36-3 C₅₈H₆₆N₄O₁₄Si 
• 709633-38-5 C₅₆H₇₀N₄O₁₄Si 
• 618428-02-7 2'-triisopropylsilyl-7-triethylsilylpaclitaxel 

Relevant articles and documents

Ni-Catalyzed asymmetric reduction of α-keto-β-lactams: via DKR enabled by proton shuttling

Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective dynamic kinetic resolution (DKR) of α-keto-β-lactams was realized via a novel proton shuttling strategy. A wide range of α-keto-β-lactams were reduced efficiently and enantioselectively by Ni-catalyzed asymmetric hydrogenation, providing the corresponding α-hydroxy-β-lactam derivatives with high yields and enantioselectivities (up to 92% yield, up to 94% ee). Deuterium-labelling experiments indicate that phenylphosphinic acid plays a pivotal role in the DKR of α-keto-β-lactams by promoting the enolization process. The synthetic potential of this protocol was demonstrated by its application in the synthesis of a key intermediate of Taxol and (+)-epi-Cytoxazone. This journal is

Borneol derivatives, methods of manufacturing them, and their pharmaceutical use

PCT No. PCT/DE96/00297 Sec. 371 Date Aug. 28, 1998 Sec. 102(e) Date Aug. 28, 1998 PCT Filed Feb. 19, 1996 PCT Pub. No. WO96/25392 PCT Pub. Date Aug. 22, 1996Borneol derivatives of formula I in which R1 to R5 and X1 to X2 are defined in the specification, and the method of making the same.