155586-39-3

Basic information

• Product Name: N,3,5-TRIMETHOXY-N-METHYLBENZAMIDE
• Synonyms: N,3,5-TRIMETHOXY-N-METHYLBENZAMIDE
• CAS NO: 155586-39-3
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.24
• Mol File: 155586-39-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 393.064°C at 760 mmHg
• Flash Point: 191.519°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: N,3,5-TRIMETHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,3,5-TRIMETHOXY-N-METHYLBENZAMIDE(155586-39-3)
• EPA Substance Registry System: N,3,5-TRIMETHOXY-N-METHYLBENZAMIDE(155586-39-3)

Safety Data

• Hazardous Substances Data: 155586-39-3(Hazardous Substances Data)

Usage

General Description

N,3,5-Trimethoxy-N-methylbenzamide is a chemical compound with the molecular formula C11H15NO4. It is a white crystalline solid that is often used as an intermediate in organic synthesis. This chemical is known for its ability to act as a pharmaceutical intermediate and is commonly used in the production of various medications. It has been used in the synthesis of potential antitumor agents and may have potential applications in pharmaceutical research and development. Additionally, it may also have uses in the production of other organic compounds and materials.

InChI:InChI=1/C11H15NO4/c1-12(16-4)11(13)8-5-9(14-2)7-10(6-8)15-3/h5-7H,1-4H3

Upstream product

• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 197587-19-2 1-(3,5-dimethoxyphenyl)-7-phenoxyheptan-1-one 
• 39192-51-3 1-(3,5-dimethoxyphenyl)heptan-1-one 
• 197587-20-5 3,5-dimethoxy-1-(2-methyl-8-phenoxyoctan-2-yl)benzene 
• 492447-05-9 1-[4-(7-bromo-1,1-dimethylheptyl)-2,6-dihydroxyphenyl]ethan-1-one 
• 492447-07-1 1-[2-allyloxy-4-(7-bromo-1,1-dimethylheptyl)-6-hydroxyphenyl]ethanone 
• 492447-03-7 1-[4-(1,1-dimethyl-7-phenoxyheptyl)-2,6-dimethoxyphenyl]ethan-1-one 
• 492447-10-6 1-[2-allyloxy-4-(7-bromo-1,1-dimethyl-heptyl)-6-hydroxy-phenyl]-10-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-7-methyl-dec-6-en-8-yn-1-one 
• 492447-12-8 1-[2-allyloxy-4-(7-bromo-1,1-dimethyl-heptyl)-6-hydroxy-phenyl]-10-(tert-butyl-dimethyl-silanyloxy)-7-methyl-dec-6-en-8-yne-1,3-diol 
• 60526-81-0 1-(1',1'-dimethylheptyl)-3,5-dimethoxybenzene 
• 303113-15-7 1-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]ethan-1-one 
• 303113-16-8 1-[4-(1,1-dimethylheptyl)-2-hydroxy-6-prop-2-enyloxyphenyl]ethan-1-one 
• 303113-17-9 (6E)-1-[4-(1,1-dimethylheptyl)-2-hydroxy-6-prop-2-enyloxyphenyl]-3-hydroxy-10-tert-butyldimethylsilyloxy-7-methyldec-6-en-8-yn-1-one 
• 303113-18-0 (6E)-1-[4-(1,1-dimethylheptyl)-2-hydroxy-6-prop-2-enyloxyphenyl]-10-tert-butyldimethylsilyloxy-7-methyldec-6-en-8-yne-1,3-diol 
• 160512-71-0 5-(8-bromo-2-methyloctan-2-yl)benzene-1,3-diol 

Relevant articles and documents

Synthesis of various acylating agents directly from carboxylic acids

A straightforward synthesis of acylating reagents such as Weinreb and MAP amides from aromatic, aliphatic carboxylic acids, and amino acids using PPh3/NBS combination is described. A chemo-selective modification of the carboxylic acid group into Weinreb amide in the presence of more reactive aldehydes and ketones is presented. All reactions were performed at ambient temperature under air using undried commercial grade solvent. Furthermore, the present methodology could be performed at a gram scale under inert-free reaction conditions. In addition, 7-azaindoline amide auxiliary (used for catalytic asymmetric aldol- and Mannich-type reactions), which behaves like Weinreb amide is also synthesized under similar reaction conditions.

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

We report the synthesis of terminally fluorinated HU-210 and HU-211 analogues (HU-210F and HU-211F, respectively) and their biological evaluation as ligands of cannabinoid receptors (CB1 and CB2) and N-methyl d-aspartate receptor (NMDAR). [18F]-labelled HU-210F was radiosynthesised from the bromo-substituted precursor. In vitro assays showed that both HU-210F and HU-211F retain the potent pharmacological profile of HU-210 and HU-211, suggesting that [18F]-radiolabelled HU-210F and HU-211F could have potential as PET tracers for in vivo imaging.

PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL

The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.