155904-35-1

Basic information

• Product Name: 3-(4-tert-butoxy-phenyl)-acrylic acid
• Synonyms: 3-(4-tert-butoxy-phenyl)-acrylic acid
• CAS NO: 155904-35-1
• Molecular Weight: 220.268
• Mol File: 155904-35-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-tert-butoxy-phenyl)-acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-tert-butoxy-phenyl)-acrylic acid(155904-35-1)
• EPA Substance Registry System: 3-(4-tert-butoxy-phenyl)-acrylic acid(155904-35-1)

Safety Data

• Hazardous Substances Data: 155904-35-1(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 57699-45-3 p-tert-butoxybenzaldehyde 
• 60876-70-2 4-tert-butoxybromobenzene 
• 79-10-7 acrylic acid 

Downstream Products

• 21323-98-8 3-(4-tert-butoxyphenyl)-propionic acid 
• 1400685-19-9 (E)-benzyl 2-(4-(tert-butoxy)benzyl)but-2-enoate 
• 941293-00-1 3-(4-tert-butoxyphenyl)propionaldehyde 
• 1400684-94-7 3-(4-(tert-butoxy)phenyl)-N-methoxy-N-methylpropanamide 
• 397883-85-1 (2S,3S)-2-[(S)-4-Benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-{(R)-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-2-methylcarbamoylmethyl-propionylamino}-butyrylamino)-butyrylamino]-3-methyl-pentanoic acid benzyl ester 
• 397883-84-0 (2S,3S)-2-[(S)-4-Benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-{(R)-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-2-dimethylcarbamoylmethyl-propionylamino}-butyrylamino)-butyrylamino]-3-methyl-pentanoic acid benzyl ester 
• 397883-78-2 4-(4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-tert-butoxy-benzyl)-N-(2,4-dimethoxy-benzyl)-N-methyl-4-oxo-butyramide 
• 326473-19-2 (2R)-2-(4-tert-butoxybenzyl)-N-(2,4-dimethoxybenzyl)-N-methylsuccinamic acid benzyl ester 
• 397883-83-9 (2R)-2-[4-(bis-benzyloxy-phosphoryloxy)-benzyl]-N-methyl-succinamic acid 
• 397883-82-8 (2R)-2-[4-(bis-benzyloxy-phosphoryloxy)-benzyl]-N,N-dimethyl succinamic acid 
• 397883-76-0 [3R,4S]-4-(4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-tert-butoxybenzyl)-N,N-dimethyl-4-oxo-butyramide 
• 326473-17-0 (4-S)-4-benzyl-3-[3-(4-tert-butoxyphenyl)-propionyl]-oxazolidin-2-one 
• 326473-18-1 (2R)-2-(4-tert-butoxybenzyl)-N,N-dimethylsuccinamic acid benzyl ester 

Relevant articles and documents

Design strategies for the sequence-based mimicry of side-chain display in protein β-sheets by α/β-peptides

The sophistication of folding patterns and functions displayed by unnatural-backbone oligomers has increased tremendously in recent years. Design strategies for the mimicry of tertiary structures seem within reach; however, a general method for the mimicry of sheet segments in the context of a folded protein is an unmet need preventing realization of this goal. Previous work has shown that 1→1 α→β-residue substitutions at cross-strand positions in a hairpin-forming α-peptide sequence can generate an α/β-peptide analogue that folds in aqueous conditions but with a change in side-chain display relative to the natural sequence; this change would prevent application of single β-residue substitutions in a larger protein. Here, we evaluate four different substitution strategies based on replacement of αα dipeptide segments for the ability to retain both sheet folding encoded by a parent α-peptide sequence as well as nativelike side-chain display in the vicinity of the β-residue insertion point. High-resolution structure determination and thermodynamic analysis of folding by multidimensional NMR suggest that three of the four designs examined are applicable to larger proteins.

Use of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics in SH2 antagonists

Novel conformationally constrained phosphotyrosine pseudopeptide derivatives of the tetrapeptide pY-E-E-I were prepared and evaluated as SH2 binding antagonists. (C) 2000 Elsevier Science Ltd.