156147-58-9

Basic information

• Product Name: Benzene, 1-[(cyclohexyloxy)methyl]-4-methoxy-
• CAS NO: 156147-58-9
• Molecular Formula: C14H20O2
• Molecular Weight: 220.312
• Mol File: 156147-58-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(cyclohexyloxy)methyl]-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(cyclohexyloxy)methyl]-4-methoxy-(156147-58-9)
• EPA Substance Registry System: Benzene, 1-[(cyclohexyloxy)methyl]-4-methoxy-(156147-58-9)

Safety Data

• Hazardous Substances Data: 156147-58-9(Hazardous Substances Data)

Upstream product

• 180259-48-7 1-methoxy-4-((pent-4-en-1-yloxy)methyl)benzene 
• 108-93-0 cyclohexanol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 866124-70-1 p-methoxybenzyloxydiphenylphosphine 
• 127866-65-3 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole 
• 824-94-2 p-methoxybenzyl chloride 
• 108-94-1 cyclohexanone 

Downstream Products

• 622-45-7 cyclohexyl acetate 
• 104-21-2 p-methoxybenzyl acetate 
• 108-93-0 cyclohexanol 

Relevant articles and documents

Direct and efficient synthesis of unsymmetrical ethers from alcohols catalyzed by Fe(HSO4)3 under solvent-free conditions

Highly efficient Fe(HSO4)3 catalyzed etherification of primary, secondary and tertiary benzylic alcohols with primary and secondary aliphatic alcohols is reported. The reaction affords unsymmetrical benzyl ethers in good to excellent yields under solvent-free conditions.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.

Benzylation of hydroxy groups with tertiary amine as a base

The benzylation of hydroxy groups in the presence of tertiary amines is described. A mixture of an alcohol and a benzyl halide afforded the corresponding benzyl ether in good to excellent yields in the presence of diisopropylethylamine. The importance of solventless conditions was observed. The reaction showed high tolerance to many functional groups including benzoate, even at a reaction temperature of 150 °C. Sodium iodide was found to be an efficient catalyst to accelerate the reaction.