127866-65-3

Basic information

• Product Name: 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole
• Synonyms: 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole
• CAS NO: 127866-65-3
• Molecular Weight: 298.368
• Mol File: 127866-65-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole(127866-65-3)
• EPA Substance Registry System: 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole(127866-65-3)

Safety Data

• Hazardous Substances Data: 127866-65-3(Hazardous Substances Data)

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 53218-10-3 4-methoxybenzyl 4-nitrobenzoate 
• 24318-43-2 4-methoxybenzyl 4-methoxybenzoate 
• 24318-41-0 p-methoxybenzyl benzoate 
• 104-21-2 p-methoxybenzyl acetate 
• 105-13-5 4-Methoxybenzyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 
• 32276-00-9 S,S-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate 
• 90673-97-5 methanesulfonic acid 4-methoxybenzyl ester 

Downstream Products

• 14248-23-8 methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate 
• 1036244-24-2 5-(4-methoxyphenylmethanesulfonyl)-1-phenyl-1H-tetrazole 
• 189366-67-4 3-(4-methoxybenzyloxy)-2-methyl-1-propene 
• 5405-95-8 4,4'-dimethoxydibenzyl ether 
• 156147-58-9 1-((cyclohexyloxy)methyl)-4-methoxybenzene 
• 17229-19-5 p-methoxybenzyl-2-chloroethylether 
• 1187667-19-1 (4-(p-methoxybenzyloxy)butoxy)triethylsilane 
• 862476-73-1 allyl-3-O-(p-methoxybenzyl)-4,6-O-benzylidene-α-D-mannopyranoside 
• 4039-83-2 3-(4-methoxybenzyloxy)propyne 
• 1187667-24-8 (2-(4-methoxybenzyloxy)-2-phenylethyl)trimethylsilane 
• 82529-79-1 4-methoxybenzyl phenethyl ether 
• 1187667-14-6 1-methoxy-4-{[(2-phenylpropan-2-yl)oxy]methyl}benzene 
• 1187667-17-9 tert-butyl (3-((4-methoxybenzyl)oxy)propyl)carbamate 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 

Relevant articles and documents

A note on the antitubercular activities of 1-aryl-5- benzylsulfanyltetrazoles

A set of 32 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis. The activity against M. tuberculosis becomes higher with increasing electron-accepting properties of the substituents on the phenyl ring. On the other hand, any substitution on the benzylic moiety decreases the activity.

One-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols

A method for one-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols and thiols is reported. A variety of primary alcohols were converted to the corresponding mesylates by methansulfonyl chloride and triethylamine in THF. After the reaction is complete, thiol (1 or 10) and either NaH or t-BuOK were added. The Julia-Kocienski sulfides 3, 9 and 11 were prepared by one-pot two steps procedure from alcohols in 76–96% yields (16 examples). Furthermore, after the sulfide formation, the reaction mixture was neutralized by p-toluenesulfonic acid and treated with H2O2 and ammonium molybdate in EtOH to give the Julia-Kocienski sulfones 4 in good yields except for trans-2-hexen-1-ol.

Ga(OTf)3-catalyzed direct substitution of alcohols with sulfur nucleophiles

It is reported that Ga(OTf)3 catalyzes the direct displacement of alcohols with sulfur nucleophiles. The products are versatile intermediates that can be utilized in carbon - carbon, carbon - sulfur bond formation or used in modified Julia olef