90673-97-5

Basic information

• Product Name: methanesulfonic acid 4-methoxybenzyl ester
• Synonyms: methanesulfonic acid 4-methoxybenzyl ester
• CAS NO: 90673-97-5
• Molecular Weight: 216.258
• Mol File: 90673-97-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 4-methoxybenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 4-methoxybenzyl ester(90673-97-5)
• EPA Substance Registry System: methanesulfonic acid 4-methoxybenzyl ester(90673-97-5)

Safety Data

• Hazardous Substances Data: 90673-97-5(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 121-98-2 methyl 4-methoxybenzoate 
• 124-63-0 methanesulfonyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 127866-65-3 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole 
• 142957-94-6 4-(4-methoxybenzyl)-1,1'-biphenyl 
• 53039-52-4 1-methyl-2-(4-methoxybenzyl) benzene 
• 726-18-1 4,4'-dianisylmethane 
• 834-14-0 p-benzylanizole 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 735265-00-6 1-(6-Chloro-3-pyridinyl)-2-(4-methoxyphenyl)ethanone 
• 171492-76-5 8-(4-methoxybenzyl)-1,4-dioxaspiro[4,5]decane 
• 221534-10-7 4-(4-methoxy-benzylidene)-cyclohexanone 
• 171492-75-4 8-(4-methoxybenzylidene)-1,4-dioxaspiro<4.5>decane 
• 67807-29-8 4-(4-methoxybenzyl)cyclohexanone 

Relevant articles and documents

Synthesis of N-alkylated pyrazolo[3,4-d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Fused pyrimidines, especially pyrazolo[3,4-d]pyrimidines, are among the most preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of biological activity. In this study, new derivatives of pyrazolo[3,4-d]pyrimidine were synthesized by alkylation of the N1 nitrogen atom. We synthesized 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2 from commercially available aminopyrazolopyrimidine 1 using N-iodosuccinimide as an iodinating agent. The synthesis of compound 2 started with nucleophilic substitution of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine with R–X (X: –OMs, –Br, –Cl), affording?N-alkylated pyrazolo[3,4-d]pyrimidine. We performed this synthesis using a weak inorganic base?and the mild temperature was also used for a two-step procedure to generate N-alkylated pyrazolo[3,4-d]pyrimidine derivatives. Also, all compounds were tested for their ability to inhibit acetylcholinesterase (AChE) and the human carbonic anhydrase (hCA) isoforms I and II, with Ki values in the range of 15.41 ± 1.39–63.03 ± 10.68 nM for AChE, 17.68 ± 1.92–66.27 ± 5.43 nM for hCA I, and 8.41 ± 2.03–28.60 ± 7.32 nM for hCA II. Notably, compound 10 was the most selective and potent CA I inhibitor with a significant selectivity ratio of 26.90.

Compound as well as preparation method and application thereof

The invention relates to a compound. The structural formula of the compound is shown as formula (1) in the description, wherein R is H or CH3. The invention further provides a preparation method of the compound and an application of the compound or pharmaceutically acceptable salt, solvate or drug complex of the compound to preparation of drugs for treating hedgehog pathway activation-related diseases. The compound can be used for preparing the drugs for treating the hedgehog pathway activation-related diseases, can well inhibit medulloblastoma growth and can be used for preparing drugs for treating medulloblastoma-related diseases.

One-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols

A method for one-pot preparation of Julia-Kocienski sulfides and sulfones from alcohols and thiols is reported. A variety of primary alcohols were converted to the corresponding mesylates by methansulfonyl chloride and triethylamine in THF. After the reaction is complete, thiol (1 or 10) and either NaH or t-BuOK were added. The Julia-Kocienski sulfides 3, 9 and 11 were prepared by one-pot two steps procedure from alcohols in 76–96% yields (16 examples). Furthermore, after the sulfide formation, the reaction mixture was neutralized by p-toluenesulfonic acid and treated with H2O2 and ammonium molybdate in EtOH to give the Julia-Kocienski sulfones 4 in good yields except for trans-2-hexen-1-ol.