82529-79-1

Basic information

• Product Name: Benzene, 1-methoxy-4-[(2-phenylethoxy)methyl]-
• CAS NO: 82529-79-1
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol File: 82529-79-1.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-[(2-phenylethoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[(2-phenylethoxy)methyl]-(82529-79-1)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[(2-phenylethoxy)methyl]-(82529-79-1)

Safety Data

• Hazardous Substances Data: 82529-79-1(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 103-45-7 acetic acid phenethyl ester 
• 100-44-7 benzyl chloride 
• 60-12-8 2-phenylethanol 
• 127866-65-3 5-[(4-methoxybenzyl)sulfanyl]-1-phenyl-1H-tetrazole 
• 105-13-5 4-Methoxybenzyl alcohol 
• 866124-70-1 p-methoxybenzyloxydiphenylphosphine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 350848-02-1 2-[(4-methoxybenzyl)oxy]-3-nitropyridine 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 

Downstream Products

• 60-12-8 2-phenylethanol 
• 83318-92-7 ethyl p-methoxybenzyl sulfide 
• 123-11-5 4-methoxy-benzaldehyde 
• 54673-12-0 (2-(methoxymethoxy)ethyl)benzene 
• 101746-67-2 bis(2-phenylethyloxy)methane 

Relevant articles and documents

Zirconium-catalysed direct substitution of alcohols: enhancing the selectivity by kinetic analysis

Kinetic analysis was used as a tool for rational optimization of a catalytic, direct substitution of alcohols to enable the selective formation of unsymmetrical ethers, thioethers, and Friedel-Crafts alkylation products using a moisture-tolerant and commercially available zirconium complex (2 to 8 mol%). Operating in air and in the absence of dehydration techniques, the protocol furnished a variety of products in high yields, including glycosylated alcohols and sterically hindered ethers. In addition, the kinetic studies provided mechanistic insight into the network of parallel transformations that take place in the reaction, and helped to elucidate the nature of the operating catalyst.

A gold catalytic the method for synthesizing calls the ether

The invention provides a synthetic method of asymmetrical ether in the field of organic synthesis. The general equation of reaction is defined in the specification. In the equation, R-OH is benzyl alcohol, p-methoxy benzyl alcohol, tert-butyl alcohol, diphenyl carbinol or triphenylmethanol; and R'OH is common alkyl alcohol or a compound containing hydroxyl groups. A gold catalyst required by the reaction is Ph3PAuCl, Ph3PAuNTf2, HAuCl4, NaAuCl4, Ph3PAuOTf, Ph3PAuSbF6, IPrAuCl or nano-gold. A medium required by the reaction is solvent-free, and is toluene, mesitylene, 1,2-dichloroethane, tetrahydrofuran, acetonitrile or acetone. The reaction is implemented by heating through a microwave reactor. The method has advantages as follows: raw materials are easily available; operation is simple; the range of application is wide; atom economy is good; and the reaction is green.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.