15657-96-2Relevant articles and documents
Hydroacetoxylation of olefins with acetic acid genetated in situ from vinyl acetate in the presence of ruthenium complexes
Khusnutdinov,Shchadneva,Khisamova,Dzhemilev
experimental part, p. 155 - 160 (2011/05/03)
Ruthenium complexes catalyze the decomposition of vinyl acetate releasing the acetic acid and its subsequent addition to linear and cyclic olefins.
Processes for producing alpha -cyanohydrin esters and alpha -hydroxy acids
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, (2008/06/13)
In the presence of a metal catalyst such as a samarium compound, an enol ester compound shown by the formula (1) is reacted with a carbonyl compound shown by the formula (3) and a cyanogenation agent to produce an alpha -cyanohydrin ester shown by the formula (4): wherein R1, R7, and R8 are the same or different from each other, each representing a non-reactive atom or a non-reactive organic group; R2, R3, and R4 are the same or different from each other, each representing a hydrogen atom or an alkyl group having 1 to 5 carbon atoms. By hydrolyzing the obtained compound, the corresponding alpha -hydroxy acid or a salt thereof can be obtained. According to the above processes, an alpha -cyanohydrin ester and an alpha -hydroxy acid can be obtained in high yields.
DABCO-Mediated Synthesis and Biological Activity of Cyanihydrin Esters
Hoffmann, H. M. R.,Ismail, Z. M.,Hollweg, Reiner,Zein, Abdul R.
, p. 1807 - 1810 (2007/10/02)
Cyanohydrin esters 1-31 have been prepared from α-ketonitriles and aldehydes using DABCO (1,4-diazabicyclooctane) as nucleophilic acylation catalyst.The modofied piperonal 8 was found to inhibit the formation of thromboxane synthetase.