157020-35-4Relevant articles and documents
A novel enantioselective synthesis of (+)-biotin
Deroose, Frederik D.,De Clercq, Pierre J.
, p. 2615 - 2618 (1994)
A conceptually attractive enantioselective 12-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cycloaddition sequence involving as key-steps (i) the macrothiolactonisation of acid 3 to Z-olefin (4), (ii) the thermolysis of the ene carbamoyl azide 5 in water with direct formation of a mixture of the benzylated derivative of (+)-biotin 6a and 6b.