157604-32-5

Basic information

• Product Name: Cyclohexanol, 2-(2-methylphenyl)-, (1R,2S)-
• CAS NO: 157604-32-5
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol File: 157604-32-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 2-(2-methylphenyl)-, (1R,2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 2-(2-methylphenyl)-, (1R,2S)-(157604-32-5)
• EPA Substance Registry System: Cyclohexanol, 2-(2-methylphenyl)-, (1R,2S)-(157604-32-5)

Safety Data

• Hazardous Substances Data: 157604-32-5(Hazardous Substances Data)

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 932-31-0 ortho-tolylmagnesium bromide 
• 523-25-1 (+/-)-trans-2-(2-methylphenyl)cyclohexan-1-ol 
• 6699-93-0 (2-methylphenyl)lithium 
• 63882-42-8 2-(2-methylphenyl)cyclohexanone 

Relevant articles and documents

Nonenzymatic kinetic resolution of secondary alcohols: Enantioselective SN2 displacement of hydroxy groups by halogens in the presence of chiral BINAP

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Synthesis method of chiral trans-2-substituted naphthenic alcohol

The invention relates to a synthesis method of chiral trans-2-substituted naphthenic alcohol. The invention provides a method for synthesizing chiral trans-cycloalkanol through asymmetric hydrogenation of palladium-catalyzed 2-substituted cyclic ketone. According to the method,a chiral diphosphine P-P * complex of metal palladium is taken as a catalyst, an acid additive is used in cooperation, asymmetric hydrogenation is carried out on a 2-substituted cyclic ketone compound to obtain a corresponding chiral trans-cycloalkanol compound. the enantiomeric excess of the chiral trans-cycloalkanol compound can reach 97% at most, and the trans-selectivity of the chiral trans-cycloalkanol compound is up to 20: 1. The method is simple and convenient to operate, practical, easy to implement, high in yield, high in atom economy and environment-friendly; the catalyst is commercially available; the reaction conditions are mild; and the method has a potential practical application value.

Organolithium/chiral Lewis base/BF3: A versatile combination for the enantioselective desymmetrization of meso-epoxides

BF3 can be used in combination with organolithium/strong Lewis base complexes for the enantioselective nucleophilic ring-opening or the carbenoidic rearrangement of various meso-oxiranes with excellent yields and ee values of up to 87%. Mechanistic aspects of these reactions are considered. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.