157793-52-7

Basic information

• Product Name: p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate
• Synonyms: p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate
• CAS NO: 157793-52-7
• Molecular Weight: 719.128
• Mol File: 157793-52-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate(157793-52-7)
• EPA Substance Registry System: p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate(157793-52-7)

Safety Data

• Hazardous Substances Data: 157793-52-7(Hazardous Substances Data)

Upstream product

• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 106-48-9 4-chloro-phenol 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50571-26-1 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 

Downstream Products

• 65062-60-4 4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 238402-95-4 C₅₂H₅₄ClN₄O₁₆P 
• 71459-54-6 C₅₄H₅₂ClN₄O₁₅P 
• 50571-26-1 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 157793-53-8 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N-butylphosphonamidate 
• 105784-94-9 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate 

Relevant articles and documents

Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks

Ammonium 4-methylphenyl H-phosphonate 4c was used in the conversion of 5'-0-(dimethoxy-trityl)-2'-deoxynucleoside derivatives 6 into the corresponding 3'-H-phosphonates 2, which were isolated in a high state of purity and in high yield.

Aryl H-phosphonates. Part 11. Synthetic and 31P NMR studies on the formation of aryl nucleoside H-phosphonates

The formation of aryl H-phosphonate diesters from the corresponding nucleoside 3′-H-phosphonates and various phenols was investigated in detail using 31P NMR spectroscopy. The major reaction pathways of aryl nucleoside H-phosphonates under diff