1578-62-7

Basic information

• Product Name: 2-Fluoro-3-methylbutyric acid
• Synonyms: 2-Fluoro-3-methylbutyric acid;2-fluoro-3-Methylbutanoic acid;Butanoic acid, 2-fluoro-3-Methyl-
• CAS NO: 1578-62-7
• Molecular Formula: C₅H₉FO₂
• Molecular Weight: 120.1222
• Mol File: 1578-62-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 35-40℃
• Boiling Point: 182℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.073
• Vapor Pressure: 0.383mmHg at 25°C
• Refractive Index: 1.395
• Storage Temp.: 2-8°C
• PKA: 2.70±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-3-methylbutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-methylbutyric acid(1578-62-7)
• EPA Substance Registry System: 2-Fluoro-3-methylbutyric acid(1578-62-7)

Safety Data

• Hazardous Substances Data: 1578-62-7(Hazardous Substances Data)

Usage

General Description

2-Fluoro-3-methylbutyric acid is a chemical compound with the molecular formula C5H9FO2. It is a fluoro-substituted derivative of 3-methylbutyric acid, which is a volatile compound found in the body's metabolic processes and as a component of certain plant oils. 2-Fluoro-3-methylbutyric acid has uses in pharmaceutical research and could potentially be used in the development of new drugs. It is important to handle this chemical with care, as it may pose risks to human health and the environment if not properly managed and disposed of.

InChI:InChI=1/C5H9FO2/c1-3(2)4(6)5(7)8/h3-4H,1-2H3,(H,7,8)

Upstream product

• 1775-47-9 2-Fluor-2-isopropyl-malonsaeure-diethylester 
• 18283-04-0 2-Ethoxycarbonimidoyl-2-fluoro-3-methyl-butyric acid ethyl ester 
• 516-06-3 D,L-valine 
• 135359-27-2 2-Fluoro-3-methyl-butyric acid methyl ester 
• 17417-00-4 methyl 2-hydroxy-3-methylbutanoate 
• 146746-20-5 (S)-(-)-methyl 2-methanesulfonyloxy-3-methylbutanoate 
• 3213-49-8 ethyl 2-isopropylcyanoacetate 
• 72-18-4 L-valine 
• 669074-37-7 (S)-4-Benzyl-3-((S)-2-fluoro-3-methyl-butyryl)-oxazolidin-2-one 
• 145589-03-3 (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one 
• 108-12-3 isopentanoyl chloride 
• 1116395-31-3 (S)-2-fluoro-3-methyl-butyric acid R-(+)-α-methylbenzylamine salt 

Downstream Products

• 669074-38-8 (S)-2-((S)-2-Fluoro-3-methyl-butyrylamino)-propionic acid tert-butyl ester 
• 669074-39-9 (S)-2-((S)-2-Fluoro-3-methyl-butyrylamino)-propionic acid 
• 143238-68-0 2'-<6'-((2''S-2''-fluoro-3''-methylbutanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 1190832-63-3 C₁₁H₁₅FN₂O 

Relevant articles and documents

Studies of a diastereoselective electrophilic fluorination reaction employing a cryo-flow reactor

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables. Georg Thieme Verlag Stuttgart. New York.

AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS

Compounds of formula (I), pharmaceutical compositions comprising them, and methods for their use are described.

P3 cap modified Phe*-Ala series BACE inhibitors

With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several series of P3 cap modified BACE inhibitors obtained via replacement of the P3 NHBoc moiety as seen in 3 with other polar functional groups such as amino, hydroxyl and fluorine. Several promising inhibitors emerging from this P3 cap SAR study (e.g., 15 and 19) demonstrated good enzyme inhibitory potencies (BACE-1 IC50 50 ～1 μM).