669074-39-9

Basic information

• Product Name: L-Alanine, N-[(2S)-2-fluoro-3-methyl-1-oxobutyl]-
• CAS NO: 669074-39-9
• Molecular Formula: C8H14FNO3
• Molecular Weight: 191.202
• Mol File: 669074-39-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[(2S)-2-fluoro-3-methyl-1-oxobutyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[(2S)-2-fluoro-3-methyl-1-oxobutyl]-(669074-39-9)
• EPA Substance Registry System: L-Alanine, N-[(2S)-2-fluoro-3-methyl-1-oxobutyl]-(669074-39-9)

Safety Data

• Hazardous Substances Data: 669074-39-9(Hazardous Substances Data)

Upstream product

• 145589-03-3 (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one 
• 669074-37-7 (S)-4-Benzyl-3-((S)-2-fluoro-3-methyl-butyryl)-oxazolidin-2-one 
• 108-12-3 isopentanoyl chloride 
• 1578-62-7 2S-2-fluoro-3-methylbutanoic acid 
• 669074-38-8 (S)-2-((S)-2-Fluoro-3-methyl-butyrylamino)-propionic acid tert-butyl ester 

Relevant articles and documents

P3 cap modified Phe*-Ala series BACE inhibitors

With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several series of P3 cap modified BACE inhibitors obtained via replacement of the P3 NHBoc moiety as seen in 3 with other polar functional groups such as amino, hydroxyl and fluorine. Several promising inhibitors emerging from this P3 cap SAR study (e.g., 15 and 19) demonstrated good enzyme inhibitory potencies (BACE-1 IC50 50 ～1 μM).