1578-89-8

Basic information

• Product Name: 2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one
• Synonyms: 2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one;3H-Pyrazol-3-one,2,4-dihydro-5-(4-methoxyphenyl)-
• CAS NO: 1578-89-8
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 1578-89-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 170 °C
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 12.61±0.40(Predicted)
• CAS DataBase Reference: 2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one(1578-89-8)
• EPA Substance Registry System: 2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one(1578-89-8)

Safety Data

• Hazardous Substances Data: 1578-89-8(Hazardous Substances Data)

Usage

General Description

2,4-Dihydro-5-(4-methoxyphenyl)-3H-pyrazol-3-one, also known as MCI-186, is a synthetic compound with potential neuroprotective and antioxidant properties. It has been studied for its potential therapeutic effects in conditions such as stroke, Alzheimer's disease, and Parkinson's disease. MCI-186 is thought to work by inhibiting oxidative stress and inflammation in the brain, ultimately protecting neurons and improving cognitive function. It has shown promise in preclinical and early clinical studies, although further research is needed to fully understand its potential uses and mechanisms of action.

Upstream product

• 22027-50-5 methyl 3-(4-methoxybenzoyl)acetate 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 496934-67-9 C₁₅H₁₃N₅O₂ 
• 1220111-75-0 C₁₅H₁₃N₅O₂ 
• 496932-62-8 C₂₀H₂₁N₅O₃ 
• 496932-75-3 C₁₇H₁₆N₄O₃ 
• 496932-45-7 4-[2-(4-chlorophenyl)hydrazineylidene]-5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one 
• 496932-48-0 5-(4-methoxyphenyl)-4-[2-(4-methoxyphenyl)hydrazineylidene]-2,4-dihydro-3H-pyrazol-3-one 
• 496932-53-7 C₁₈H₁₉N₅O₂ 
• 496932-72-0 C₁₆H₁₃ClN₄O₂ 
• 496932-59-3 C₁₇H₁₃N₅O₂ 
• 496932-38-8 C₂₀H₂₃N₅O₂ 

Relevant articles and documents

Design, synthesis and anticancer activity of some novel 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one derivatives

New pyrazole derivatives were designed and synthesized by the reaction of 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one (4) or 5-(4-methoxyphenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (5) with series of aldehydes, substituted amines, isatins and phenylisothiocynate to yield 6a-j, 7a-k, 9a-d and 10a-b, respectively. The synthesized compounds were examined in vitro for their anti-tumor activities against HepG-2, PC-3 and HCT-116 human carcinoma cell lines using MTT assay. Eight compounds showed good anticancer activities against HCT-116 carcinoma cells and five compounds showed good anticancer activities against PC-3 cancer cells but all the compounds showed weak or no anticancer activities against HepG-2 liver cancer.

3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3β

A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3β was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.