496932-48-0

Basic information

• Product Name: 1H-Pyrazole-4,5-dione, 3-(4-methoxyphenyl)-, 4-[(4-methoxyphenyl)hydrazone]
• CAS NO: 496932-48-0
• Molecular Formula: C17H16N4O3
• Molecular Weight: 324.339
• Mol File: 496932-48-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4,5-dione, 3-(4-methoxyphenyl)-, 4-[(4-methoxyphenyl)hydrazone](CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4,5-dione, 3-(4-methoxyphenyl)-, 4-[(4-methoxyphenyl)hydrazone](496932-48-0)
• EPA Substance Registry System: 1H-Pyrazole-4,5-dione, 3-(4-methoxyphenyl)-, 4-[(4-methoxyphenyl)hydrazone](496932-48-0)

Safety Data

• Hazardous Substances Data: 496932-48-0(Hazardous Substances Data)

Upstream product

• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 4346-59-2 para-methoxyphenyldiazonium chloride 
• 1578-89-8 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one 
• 104-94-9 4-methoxy-aniline 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Design, synthesis and anticancer activity of some novel 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one derivatives

New pyrazole derivatives were designed and synthesized by the reaction of 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one (4) or 5-(4-methoxyphenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (5) with series of aldehydes, substituted amines, isatins and phenylisothiocynate to yield 6a-j, 7a-k, 9a-d and 10a-b, respectively. The synthesized compounds were examined in vitro for their anti-tumor activities against HepG-2, PC-3 and HCT-116 human carcinoma cell lines using MTT assay. Eight compounds showed good anticancer activities against HCT-116 carcinoma cells and five compounds showed good anticancer activities against PC-3 cancer cells but all the compounds showed weak or no anticancer activities against HepG-2 liver cancer.