15795-51-4

Basic information

• Product Name: 2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione
• Synonyms: 2,2-Propanediol cyclic (p-methylbenzylidene)malonate;2,2-Dimethyl-5-(4-methylbenzylidene)-1,3-dioxane-4,6-dione
• CAS NO: 15795-51-4
• Molecular Formula: C₁₄H₁₄O₄
• Molecular Weight: 246.261
• Mol File: 15795-51-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 113-115℃
• Appearance: /
• Density: 1.207
• CAS DataBase Reference: 2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione(15795-51-4)
• EPA Substance Registry System: 2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione(15795-51-4)

Safety Data

• Hazardous Substances Data: 15795-51-4(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione is a chemical compound with the molecular formula C13H14O4. It is an organic compound that belongs to the class of dioxanes, which are cyclic organic compounds containing two oxygen atoms and four carbon atoms in a ring. 2,2-Dimethyl-5-[(4-methylphenyl)methylene]-1,3-dioxane-4,6-dione is characterized by its distinctive dioxane-4,6-dione core and a methylphenylmethylene substituent. It is used in various chemical and pharmaceutical applications, and its unique structure gives it potential as a building block for the synthesis of more complex molecules. The compound may have potential applications in the fields of organic synthesis, medicine, and materials science.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 104-87-0 4-methyl-benzaldehyde 
• 110-86-1 pyridine 
• 70-11-1 α-bromoacetophenone 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 119-65-3 isoquinoline 
• 108-99-6 3-Methylpyridine 
• 130296-61-6 5-(4-methyl-benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 19865-55-5 N-(4-methylbenzylidene)aniline oxide 

Downstream Products

• 53942-71-5 2,4-Bis(4'-methylbenzyliden)cyclobutan-1,3-dion 
• 97381-42-5 6,6-Dimethyl-1-(4-methyl-benzyl)-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 97381-39-0 6,6-Dimethyl-1-p-tolyl-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 130296-61-6 5-(4-methyl-benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 104-87-0 4-methyl-benzaldehyde 
• 99-94-5 p-Toluic acid 
• 75307-59-4 5-Hydroxy-Meldrums Saeure 
• 62054-75-5 2,2-Dimethyl-5-(1-p-tolyl-ethyl)-[1,3]dioxane-4,6-dione 
• 923602-47-5 (1-p-tolylethyl)-(3,3-dimethylallyl)malonic acid 
• 38142-58-4 (+/-)-ar-turmerone 

Relevant articles and documents

Knoevenagel condensation of aldehydes with Meldrum's acid in ionic liquids

The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF4 at room temperature in the presence of catalytic amounts of piperidine.

Uncatalyzed Knoevenagel condensation in PEG-600 at room temperature

A rapid, efficient, and ecofriendly protocol has been developed for the Knoevenagel condensation of active methylene compounds with aromatic, aliphatic, conjugated and heteroaromatic aldehydes in polyethylene glycol-600 (PEG-600) with good to excellent yi

Enantioselective Ammonium Ylide Mediated One-Pot Synthesis of Highly Substituted γ-Butyrolactones

An ammonium ylide mediated access towards trans-β,γ-disubstituted, all-trans-α,β,γ-trisubstituted, and α,α,β,γ-tetrasubstituted γ-butyrolactones bearing a broad variety of functionalities was developed. Starting from widely accessible benzylidene Meldrum's acid derivatives and α-bromo carbonyl compounds, γ-butyrolactones were obtained in yields between 32–99% with up to excellent diastereoselectivities (>95:5) via a DABCO-mediated [2+1] annulation. Utilization of enantiomerically pure cinchona alkaloid derivatives enables the first asymmetric ammonium ylide mediated method to provide (3R,?4R)-β,γ-disubstituted and (2R,?3R,?4R)-α,β,γ-trisubstituted γ-butyrolactones in moderate to good yields with up to very good enantiomeric ratios (97:3). The scalability of the transformation was proven while determining the absolute configuration. (Figure presented.).

An alternative, practical, and ecological protocol for synthesis of arylidene analogues of Meldrum’s acid as useful intermediates

This paper presents an ecological protocol for Knoevenagel condensation using a catalytic amount of 4,4′-trimethylenedipiperidine as a versatile, efficient, safe, commercially available, inexpensive, and recyclable organocatalyst by a ball-milling process