97381-39-0

Basic information

• Product Name: 5,7-Dioxaspiro[2.5]octane-4,8-dione, 6,6-dimethyl-1-(4-methylphenyl)-
• CAS NO: 97381-39-0
• Molecular Formula: C15H16O4
• Molecular Weight: 260.29
• Mol File: 97381-39-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5,7-Dioxaspiro[2.5]octane-4,8-dione, 6,6-dimethyl-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dioxaspiro[2.5]octane-4,8-dione, 6,6-dimethyl-1-(4-methylphenyl)-(97381-39-0)
• EPA Substance Registry System: 5,7-Dioxaspiro[2.5]octane-4,8-dione, 6,6-dimethyl-1-(4-methylphenyl)-(97381-39-0)

Safety Data

• Hazardous Substances Data: 97381-39-0(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 15795-51-4 2,2-dimethyl-5-(4-methylbenzylidene)-1,3-dioxane-4,6-dione 
• 70775-39-2 dimethylsulfoxonium methylide 
• 186581-53-3 diazomethane 

Downstream Products

• 97364-83-5 (1R,2S)-2-p-Tolyl-cyclopropane-1,1-dicarboxylic acid methyl ester 
• 97364-53-9 (1R,2R)-1-Carbamoyl-2-p-tolyl-cyclopropanecarboxylic acid 
• 97364-66-4 (3S,5R)-2-Oxo-5-p-tolyl-pyrrolidine-3-carboxylic acid 
• 97364-66-4 (3R,5R)-2-Oxo-5-p-tolyl-pyrrolidine-3-carboxylic acid 

Relevant articles and documents

Diazo compounds and phenyliodonium ylides in inter- and intramolecular cyclopropanations catalyzed by dirhodium(II). Synthesis and chiral resolution by GC versus HPLC

The dirhodium(II)-catalyzed intermolecular cyclopropanation of a set of olefins with either diazo free phenyliodonium ylides or diazo compounds afforded cyclopropanes derived from Meldrum's acid, dimethyl malonate, (silanoxyvinyl)diazoacetates, 3,3,3-trifluoro-2-diazopropionate, ethyl diazo(triethyl)- and (dimethylphenyl)silylacetate with moderate to high yield in either racemic or enantio-enriched forms. The intramolecular cyclopropanation of triethylsilyl-substituted allyl diazo-acetates in the presence of the chiral rhodium(II) catalyst [Rh2(s-nttl)4] in toluene afforded the corresponding cyclopropanes with up to 37% ee. An efficient chiral separation method based on enantioselective GC and HPLC was developed. The method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the inter- and intramolecular cyclopropanation reactions and avoids time-consuming work-up procedures. Springer-Verlag 2005.