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1579960-78-3

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1579960-78-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1579960-78-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,7,9,9,6 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1579960-78:
(9*1)+(8*5)+(7*7)+(6*9)+(5*9)+(4*6)+(3*0)+(2*7)+(1*8)=243
243 % 10 = 3
So 1579960-78-3 is a valid CAS Registry Number.

1579960-78-3Downstream Products

1579960-78-3Relevant articles and documents

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Jia, Jian-Min,Liu, Fang,Xu, Xiao-Li,Guo, Xiao-Ke,Jiang, Fen,Cherfaoui, Bahidja,Sun, Hao-Peng,You, Qi-Dong

, p. 1557 - 1561 (2014/03/21)

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.

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