199105-19-6 Usage
General Description
N-[2-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride is a chemical compound with the molecular formula C12H19N3O2S?HCl. It is a sulfonamide derivative with a piperazine group, commonly used as an anti-bacterial and anti-inflammatory agent. N-[2-(PIPERAZIN-1-YL)PHENYL]METHYLSULPHONAMIDE HYDROCHLORIDE is known to have antibacterial properties and is used in the treatment of various infections. It acts by inhibiting the synthesis of folic acid in bacteria, ultimately leading to their death. Additionally, it has also shown potential in the treatment of certain inflammatory conditions. N-[2-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride is commonly used in pharmaceutical formulations and medical research.
Check Digit Verification of cas no
The CAS Registry Mumber 199105-19-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,1,0 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 199105-19:
(8*1)+(7*9)+(6*9)+(5*1)+(4*0)+(3*5)+(2*1)+(1*9)=156
156 % 10 = 6
So 199105-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H17N3O2S.ClH/c1-17(15,16)13-10-4-2-3-5-11(10)14-8-6-12-7-9-14;/h2-5,12-13H,6-9H2,1H3;1H
199105-19-6Relevant articles and documents
Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold
Jia, Jian-Min,Liu, Fang,Xu, Xiao-Li,Guo, Xiao-Ke,Jiang, Fen,Cherfaoui, Bahidja,Sun, Hao-Peng,You, Qi-Dong
, p. 1557 - 1561 (2014/03/21)
Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.
Serine derived NK1 antagonists 2: A pharmacophore model for arylsulfonamide binding
Elliott,Broughton,Cascieri,Chicchi,Huscroft,Kurtz,MacLeod,Sadowski,Stevenson
, p. 1851 - 1856 (2007/10/03)
Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.