1580465-77-5

Basic information

• Product Name: N¹-(2,4-dibromo-5-methoxybenzyl)-N³,N³-dimethylpropane-1,3-diamine
• Synonyms: N¹-(2,4-dibromo-5-methoxybenzyl)-N³,N³-dimethylpropane-1,3-diamine
• CAS NO: 1580465-77-5
• Molecular Weight: 380.123
• Mol File: 1580465-77-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N¹-(2,4-dibromo-5-methoxybenzyl)-N³,N³-dimethylpropane-1,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-(2,4-dibromo-5-methoxybenzyl)-N³,N³-dimethylpropane-1,3-diamine(1580465-77-5)
• EPA Substance Registry System: N¹-(2,4-dibromo-5-methoxybenzyl)-N³,N³-dimethylpropane-1,3-diamine(1580465-77-5)

Safety Data

• Hazardous Substances Data: 1580465-77-5(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 99615-74-4 2,4-dibromo-5-methoxylbenzaldehyde 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 3111-51-1 2,4-dibromo-5-hydroxybenzaldehyde 

Relevant articles and documents

N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).