158205-19-7

Basic information

• Product Name: 5-amino-6-bromo-2,3-dihydro-1H-inden-1-one
• Synonyms: 5-amino-6-bromo-2,3-didydro-1H-inden-1-one
• CAS NO: 158205-19-7
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.0699
• Mol File: 158205-19-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 376.725°C at 760 mmHg
• Flash Point: 181.637°C
• Density: 1.694g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: 5-amino-6-bromo-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-6-bromo-2,3-dihydro-1H-inden-1-one(158205-19-7)
• EPA Substance Registry System: 5-amino-6-bromo-2,3-dihydro-1H-inden-1-one(158205-19-7)

Safety Data

• Hazardous Substances Data: 158205-19-7(Hazardous Substances Data)

Usage

General Description

5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is a chemical compound that belongs to the class of inden-1-one derivatives. It is a yellow solid with the molecular formula C9H8BrNO and a molecular weight of 228.07 g/mol. 5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one is a synthetic intermediate used in organic synthesis and pharmaceutical research. It has potential applications in the development of drugs and agrochemicals due to its unique chemical structure and reactivity. 5-Amino-6-bromo-2,3-dihydro-1H-inden-1-one may also have other industrial applications and is of interest to researchers and chemists in the field of organic chemistry.

Upstream product

• 158205-18-6 5-Acetylamino-6-bromo-1-indanone 
• 24425-40-9 indan-5-amine 
• 157701-33-2 5-acetylamino-6-bromoindane 
• 59856-06-3 5-acetamidoindane 

Downstream Products

• 501170-72-5 5-benzyloxyacetamido-6-bromoindan-1-one 
• 501170-90-7 tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate 
• 501170-76-9 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-bromoindan-1-yl)amino]benzoate 
• 501132-07-6 tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoate 
• 501170-80-5 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-cyanoindan-1-yl)amino]benzoate 
• 501170-85-0 tert-butyl 4-{N-[2-benzyloxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate 
• 158205-23-3 5-amino-6-<(2,4-difluorophenyl)thio>-1-indanone 
• 158205-05-1 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone 
• 158205-22-2 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal 
• 170456-58-3 5--6-(2,4-difluorophenylthio)-1-indanone 
• 1027528-84-2 5-Amino-6-cyclohexylsulfanyl-indan-1-one 
• 1027831-58-8 5-Amino-6-m-tolylsulfanyl-indan-1-one 
• 1027497-01-3 5-Amino-6-o-tolylsulfanyl-indan-1-one 
• 1026678-70-5 5-Amino-6-(4-ethyl-phenylsulfanyl)-indan-1-one 

Relevant articles and documents

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity

IRAK4 kinase activity transduces signaling from multiple IL-1Rs and TLRs to regulate cytokines and chemokines implicated in inflammatory diseases. As such, there is high interest in identifying selective IRAK4 inhibitors for the treatment of these disorders. We previously reported the discovery of potent and selective dihydrobenzofuran inhibitors of IRAK4. Subsequent studies, however, showed inconsistent inhibition in disease-relevant pharmacodynamic models. Herein, we describe application of a human whole blood assay to the discovery of a series of benzolactam IRAK4 inhibitors. We identified potent molecule 19 that achieves robust in vivo inhibition of cytokines relevant to human disease.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (0), Formula (I), and Formula (II) and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.