501170-90-7

Basic information

• Product Name: tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate
• Synonyms: tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate
• CAS NO: 501170-90-7
• Molecular Weight: 407.469
• Mol File: 501170-90-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate(501170-90-7)
• EPA Substance Registry System: tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate(501170-90-7)

Safety Data

• Hazardous Substances Data: 501170-90-7(Hazardous Substances Data)

Upstream product

• 158205-18-6 5-Acetylamino-6-bromo-1-indanone 
• 158205-19-7 5-Amino-6-bromo-1-indanone 
• 501170-80-5 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-cyanoindan-1-yl)amino]benzoate 
• 501170-76-9 tert-butyl 4-[N-(5-(2-benzyloxy-ethanoylamino)-6-bromoindan-1-yl)amino]benzoate 
• 501170-72-5 5-benzyloxyacetamido-6-bromoindan-1-one 
• 501170-85-0 tert-butyl 4-{N-[2-benzyloxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino}benzoate 

Downstream Products

• 501132-07-6 tert-butyl 4-{N-[2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoate 

Relevant articles and documents

Cyclopenta[g]quinazolinone-based inhibitors of thymidylate synthase targeting α-folate receptor overexpressing tumours: synthetic approaches to 4-{N-[(6RS)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benz

An advanced intermediate for the synthesis of cyclopenta[g]quinazolinone-based antifolates such as (6RS)-CB300945 was prepared by a convergent methodology. The oxo-functionality required for the formation of the C-6-N-10 bond in 4 was introduced in the in