158469-52-4

Basic information

• Product Name: Ethyl (Z)-3-<3-<4-(3-hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>acrylate
• Synonyms: Ethyl (Z)-3-<3-<4-(3-hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>acrylate
• CAS NO: 158469-52-4
• Molecular Weight: 464.582
• Mol File: 158469-52-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl (Z)-3-<3-<4-(3-hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (Z)-3-<3-<4-(3-hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>acrylate(158469-52-4)
• EPA Substance Registry System: Ethyl (Z)-3-<3-<4-(3-hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>acrylate(158469-52-4)

Safety Data

• Hazardous Substances Data: 158469-52-4(Hazardous Substances Data)

Upstream product

• 82101-76-6 (Z)-ethyl 3-(tributylstannyl)propenoate 
• 158469-51-3 3-<4-(5-Iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propan-1-ol 
• 1026324-32-2 Methyl 3-<4-(5-iodo-2-methoxyphenoxy)phenyl>-3-(phenylsulfanyl)propionate 
• 158469-50-2 Methyl (Z)-3-<4-(5-iodo-2-methoxyphenoxy)phenyl>acrylate 
• 158469-49-9 4-(5-Iodo-2-methoxyphenoxy)benzonitrile 
• 158469-55-7 4-(5-Iodo-2-methoxyphenoxy)benzaldehyde 
• 90-05-1 2-methoxy-phenol 
• 78338-67-7 4-(2'-methoxyphenoxy)benzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 158469-53-5 3-<3-<4-(3-Hydroxy-1-(phenylsulfanyl)propyl)phenoxy>-4-methoxyphenyl>propionic acid 
• 158469-54-6 4-Methoxy-14-(phenylsulfanyl)-2,11-dioxatricyclo<13.2.2.1^3,7>eicosa-1(18),3,5,7(20),1(19),16-hexaen-10-one 
• 158469-57-9 4-Hydroxy-14-(phenylsulfanyl)-2,11-dioxatricyclo<13.2.2.1^3,7>eicosa-1(18),3,5,7(20),1(19),16-hexaen-10-one 
• 126191-23-9 combretastatin D-2 

Relevant articles and documents

Synthesis of (±)-combretastatin D-1 and combretastatin D-2

(±)-Combretastatin D-1 was synthesized in 16 steps by way of its congener, combretastatin D-2. In the key step, the strained 15-membered lactone ring was formed using high-dilution Mitsunobu conditions in 89% yield. Saturated seco acid 4 was a much better substrate for the cyclization reaction than the unsaturated seco acid 3.