15850-29-0

Basic information

• Product Name: 4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE
• Synonyms: TIMTEC-BB SBB007394;CHEMBRDG-BB 3006170;AURORA 5373;4-(4-ETHOXYPHENYL)-1,3-THIAZOL-2-AMINE;4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE;AKOS BC-2725;AKOS BBS-00007976;4-(4-ethoxyphenyl)-1,3-thiazol-2-amine(SALTDATA: FREE)
• CAS NO: 15850-29-0
• Molecular Formula: C₁₁H₁₂N₂OS
• Molecular Weight: 220.29
• Mol File: 15850-29-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.8°C at 760 mmHg
• Flash Point: 198.6°C
• Appearance: /
• Density: 1.222g/cm³
• Vapor Pressure: 9.18E-07mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE(15850-29-0)
• EPA Substance Registry System: 4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE(15850-29-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 15850-29-0(Hazardous Substances Data)

Usage

General Description

4-(4-ethoxy-phenyl)-thiazol-2-ylamine is a chemical compound with the molecular formula C12H12N2OS. It belongs to the thiazole class of compounds and contains an ethoxyphenyl group attached to a thiazole ring. 4-(4-ETHOXY-PHENYL)-THIAZOL-2-YLAMINE is commonly used in pharmaceutical research and development, particularly in the synthesis of various drugs and biologically active compounds. It has been studied for its potential therapeutic effects in the treatment of various diseases, including cancer and inflammatory disorders. 4-(4-ethoxy-phenyl)-thiazol-2-ylamine has also been investigated for its antimicrobial and antifungal properties, making it a valuable compound for medicinal and agricultural applications.

InChI:InChI=1/C11H12N2OS/c1-2-14-9-5-3-8(4-6-9)10-7-15-11(12)13-10/h3-7H,2H2,1H3,(H2,12,13)

Upstream product

• 17356-08-0 thiourea 
• 1676-63-7 4'-ethoxyacetophenone 
• 51012-63-6 2-bromo-4'-ethoxyacetophenone 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 398-25-4 4-fluoro-benzenesulfonic acid-[4-(4-ethoxy-phenyl)-thiazol-2-ylamide] 
• 115035-26-2 4,4'-bis-(4-ethoxy-phenyl)-5,5'-benzylidene-bis-thiazol-2-ylamine 
• 69396-09-4 N-{[4-(4-ethoxy-phenyl)-thiazol-2-ylamino]-methyl}-phthalimide 
• 50891-62-8 3-(4-ethoxy-phenyl)-6,8-dimethyl-7-nitro-pyrido[2,3-d]thiazolo[3,2-a]pyrimidin-5-ylideneamine 
• 56921-58-5 3-(4-ethoxy-phenyl)-6-p-tolyl-imidazo[2,1-b]thiazole 
• 56921-57-4 3-(4-ethoxy-phenyl)-6-(4-methoxy-phenyl)-imidazo[2,1-b]thiazole 
• 77203-60-2 2,4-Dibromo-6-{[(E)-4-(4-ethoxy-phenyl)-thiazol-2-ylimino]-methyl}-phenol 
• 113688-74-7 2-{[(E)-4-(4-Ethoxy-phenyl)-thiazol-2-ylimino]-methyl}-4-methyl-phenol 
• 97855-12-4 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-thiazol-2-yl-benzenesulfonamide 
• 97854-84-7 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-pyrimidin-2-yl-benzenesulfonamide 
• 97854-90-5 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-(2-methyl-pyrimidin-4-yl)-benzenesulfonamide 
• 97855-07-7 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide 
• 97855-23-7 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide 
• 97855-02-2 4-[2-Amino-4-(4-ethoxy-phenyl)-thiazol-5-ylazo]-N-(6-methoxy-pyridazin-3-yl)-benzenesulfonamide 

Relevant articles and documents

Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl/aryl ketones using aqueous NaICl2

A simple methodology was developed to synthesize substituted aminothiazoles from the corresponding thiourea and substituted ketones using aqueous NaICl2 at reflux temperature in THF. The products were obtained in good to excellent yields.

Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury

Myeloid differentiation primary response protein 88 (MyD88), an essential adapter protein used by toll-like receptors (TLR), is a promising target molecule for the treatment of respiratory inflammatory diseases. Previous studies explored the activities of novel 2-amino-4-phenylthiazole analogue (6) in inflammation-induced cancer, and identified the analogue as an inhibitor of MyD88 toll/interleukin-1 receptor (TIR) homology domain dimerization. Here, we describe the synthesis of 47 new analogues by modifying different sites on this lead compound and assessed their anti-inflammatory activities in lipopolysaccharide-induced mouse primary peritoneal macrophages (MPMs). The most promising compound, 15d, was found to effectively interact with MyD88 protein and prevented formation of the MyD88 homodimeric complex. Furthermore, 15d showed in vivo anti-inflammatory activity in LPS-caused model of acute lung injury. This work provides new candidates as MyD88 inhibitors to combat inflammation diseases.