1676-63-7

Basic information

• Product Name: 4'-Ethoxyacetophenone
• Synonyms: 1-(4-ethoxyphenyl)-ethanon;1-(4-Ethoxyphenyl)ethanone;1-(4-ethoxyphenyl)-Ethanone;Acetophenone, 4'-ethoxy-;Acetophenone, p-ethoxy-;4'-ETHOXYACETOPHENONE;4-ETHOXYACETOPHENONE;4-ETHOXYPHENYLETHANONE
• CAS NO: 1676-63-7
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• EINECS: 216-825-6
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Acetophenone;Organic Photoinitiators;Polymerization Initiators
• Mol File: 1676-63-7.mol
• Article Data: 42

Chemical Properties

• Melting Point: 37-39 °C(lit.)
• Boiling Point: 268-269 °C758 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: white to yellow crystals and chunks
• Density: 1.0326 (rough estimate)
• Refractive Index: 1.5180 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: Soluble in alcohol, water(791.1 mg/L).
• BRN: 636783
• CAS DataBase Reference: 4'-Ethoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Ethoxyacetophenone(1676-63-7)
• EPA Substance Registry System: 4'-Ethoxyacetophenone(1676-63-7)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-26-22
• Safety Statements: 26-37/39-45-36/37-28
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 1676-63-7(Hazardous Substances Data)

Usage

Description

4'-Ethoxyacetophenone, also known as 1-(4-ethoxyphenyl)ethanone, is an organic compound that exists in the form of white to yellow crystals or chunks. It is characterized by its chemical structure, which includes an ethoxy group attached to a phenyl ring and an acetophenone group. 4'-Ethoxyacetophenone is known for its versatile chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
4'-Ethoxyacetophenone is used as an intermediate in the synthesis of various pharmaceutical compounds. One of its primary applications is in the production of 4-(4-ethoxy-phenyl)-thiazol-2-ylamine, which is a compound with potential therapeutic properties. The versatility of 4'-Ethoxyacetophenone in chemical reactions allows for the creation of a wide range of pharmaceutical products.
Used in Chemical Synthesis:
In the field of organic chemistry, 4'-Ethoxyacetophenone serves as a valuable building block for the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a useful starting material for the development of new molecules with specific properties and applications.
Used in Research and Development:
4'-Ethoxyacetophenone is also utilized in research and development settings, where it can be employed to study the properties and reactivity of similar compounds. Its use in this context helps scientists gain a better understanding of the underlying chemical principles and can lead to the discovery of new compounds with novel applications.

InChI:InChI=1/C10H12O2/c1-3-12-10-6-4-9(5-7-10)8(2)11/h4-7H,3H2,1-2H3

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 200576-81-4 (4-ethoxy-phenacylmercapto)-acetic acid 
• 141-82-2 malonic acid 
• 108-24-7 acetic anhydride 
• 103-73-1 Phenetole 
• 56-23-5 tetrachloromethane 
• 855618-25-6 1-(4-ethoxy-cyclohexa-1,4-dienyl)-ethanone 
• 118-75-2 chloranil 
• 855618-27-8 1-(4-ethoxy-cyclohexa-1,3-dienyl)-ethanone 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 96-63-9 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 
• 125219-07-0 (S)-2-[2-(4-Ethoxy-phenyl)-2-oxo-ethoxycarbonylamino]-propionic acid methyl ester 

Downstream Products

• 102953-44-6 1-(4-ethoxy-phenyl)-3-(4-propyl-piperidino)-propan-1-one 
• 51842-68-3 2-(4-ethoxyphenyl)quinoline-4-carboxylic acid 
• 93877-79-3 (E)-1-(4-ethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 51944-10-6 1-(4-ethoxyphenyl)butane-1,3-dione 
• 60131-72-8 1-(4-ethoxy-phenyl)-1-(4-methoxy-phenyl)-ethene 
• 2675-27-6 1-(4-ethoxy-phenyl)-ethanone-(4-nitro-phenylhydrazone) 
• 101356-82-5 1-(4-ethoxy-phenyl)-3-diethylamino-propan-1-one; hydrochloride 
• 63815-42-9 1-(4-ethoxy-phenyl)-3-piperidino-propan-1-one; hydrochloride 
• 78927-73-8 5-acetyl-2-ethoxybenzyl chloride 
• 72770-46-8 3-(4-ethoxy-phenyl)-crotonic acid 
• 51725-83-8 ethyl 4-ethoxybenzoylacetate 
• 116071-56-8 1-(4-ethoxyphenyl)ethyl alcohol 
• 7252-58-6 1-(4-ethoxy-phenyl)-ethanone semicarbazone 

Relevant articles and documents

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

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Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls

An efficient electrochemical method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction.

Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide

Successive treatment of arenes with acyl chlorides and AlCl3, the addition of water and removal of solvent, the reaction with NH2OH?HCl and K2CO3, and the reaction with diphenylphosphoryl azide and DBU under warming conditions gave the corresponding 5-alkyl-1-aryltetrazoles efficiently in good to moderate yields. The present method is one-pot transformation of arenes into 5-alkyl-1-aryltetrazoles using the Friedel-Crafts acylation and the Beckmann rearrangement under transition-metal-free conditions.