15862-33-6

Basic information

• Product Name: 3-Bromo-2-hydroxy-5-nitropyridine
• Synonyms: 3-bromo-5-nitro-(6CI)-2(1H)-Pyridone;3-bromo-5-nitro-(7CI,8CI)-2-Pyridinol;3-BroMo-2-hydroxyY-5-nitropyridine;3-BROMO-5-NITRO-2(1H)-PYRIDINONE;3-BROMO-5-NITRO-2-PYRIDINOL;3-BROMO-2-HYDROXY-5-NITROPYRIDINE;3-Bromo-5-nitropyridin-2-ol;Pyridin-2-ol, 3-bromo-5-nitro-
• CAS NO: 15862-33-6
• Molecular Formula: C₅H₃BrN₂O₃
• Molecular Weight: 218.99
• EINECS: -0
• Product Categories: NitroCompounds;Pyridines;Pyridine;Pyridine Series;blocks;Bromides
• Mol File: 15862-33-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 213-218℃
• Boiling Point: 300.9 °C at 760 mmHg
• Flash Point: 135.8 °C
• Appearance: /Solid
• Density: 1.98 g/cm³
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.58±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-hydroxy-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-hydroxy-5-nitropyridine(15862-33-6)
• EPA Substance Registry System: 3-Bromo-2-hydroxy-5-nitropyridine(15862-33-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT, KEEP COLD
• Hazardous Substances Data: 15862-33-6(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-hydroxy-5-nitropyridine is a chemical compound with the molecular formula C5H3BrN2O4. It is a pyridine derivative with a bromine atom at the 3-position, a hydroxyl group at the 2-position, and a nitro group at the 5-position. 3-Bromo-2-hydroxy-5-nitropyridine is commonly used in organic synthesis as a building block for the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a reagent in chemical reactions, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. Due to its unique structure and reactivity, 3-Bromo-2-hydroxy-5-nitropyridine has applications in various industries and research fields.

InChI:InChI=1/C5H3BrN2O3/c6-4-1-3(8(10)11)2-7-5(4)9/h1-2H,(H,7,9)

Upstream product

• 5418-51-9 5-nitro-2-hydroxypyridine 
• 1868-58-2 3-bromo-2-fluoro-5-nitropyridine 

Downstream Products

• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 
• 15862-36-9 2,3-dibromo-5-nitropyridine 
• 130284-53-6 5-amino-3-bromo-2-chloropyridine 
• 130284-55-8 5-bromo-6-chloropyridin-3-yl acetate 
• 130115-85-4 5-bromo-6-chloropyridin-3-ol 
• 15862-50-7 3-bromo-2-methoxy-5-nitropyridine 
• 206759-33-3 2-isopropoxy-3-bromo-5-nitropyridine 
• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 186593-43-1 5-amino-3-bromo-2-methylpyridine 
• 1119088-68-4 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine 
• 1119088-71-9 2-(3-methoxyphenyl)-5-nitro-3-phenylpyridine 
• 1119088-65-1 6-(3-methoxyphenyl)-5-phenylpyridin-3-amine 
• 1119085-69-6 2-(6-(3-methoxyphenyl)-5-phenylpyridin-3-ylamino)-5-methylbenzoic acid 
• 1119090-69-5 ethyl 2-(6-(3-methoxyphenyl)-5-phenylpyridin-3-ylamino)-5-methylbenzoate 

Relevant articles and documents

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.

IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present disclosure is directed to compounds of formula (Ie) and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, m, n, X1, X2, X3 and X4 are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

DYE COMPOSITION COMPRISING A 1,2,3,4-TETRAHYDROPYRIDO[2,3-B]PYRAZIN-7-AMINE COMPOUND

The invention relates to a 1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-amine compound of formula (I) below, addition salts thereof, optical isomers, geometrical isomers and tautomersthereof and/or solvates thereof: in which: ?R2, R3, R4, R5, and R7 independently represent: a hydrogen or halogen atom; a C1-C4 alkyl radical; a C1-C4 hydroxyalkyl radical; a carboxyl radical; a (C1-C4)alkoxycarbonyl radical; ? R1 and R6, which may be identical or different, represent: hydrogen atom; C1-C10 and preferably Ci-C6 alkyl radical, - optionally interrupted with one or more heteroatoms chosen from O and S or with one or more groups -NR and/or - optionally terminating with at least one group -NX1X2 or at least one group -OX3, ? X1 and X2 independently denote - a hydrogen atom, a linear C1-C6 alkyl radical, a branched C3-C6 alkyl radical, a linear C1-C6 hydroxyalkyl radical or a branched C3-C6 hydroxyalkyl radical, X1 and X2 may form, with the nitrogen atom that bears them, a saturated or unsaturated 5- to 8-membered heterocycle, in which one of the ring members may be a heteroatom chosen from O, S and N; the said heterocycle possibly being substituted with one or more linear or branched C1-C4 alkyl or C1-C4 hydroxyalkyl radicals, ? X3 denotes - a hydrogen atom - a linear C1-C4 or branched C3-C4 alkyl radical, and ? R denotes - a hydrogen atom - a linear C1-C4 alkyl radical.