186593-43-1

Basic information

• Product Name: 5-AMINO-3-BROMO-2-METHYLPYRIDINE
• Synonyms: 5-AMINO-3-BROMO-2-METHYLPYRIDINE;3-Bromo-5-Amino-2-Picoline;5-Bromo-6-methylpyridin-3-amine;5-Amino-3-bromo-2-methylp...;2-Methyl-3-broMo-5-aMinopyridine;3-PyridinaMine, 5-broMo-2-chloro-6-Methyl-;5-BroMo-6-Methyl-pyridin-3-ylaMine;5-AMINO-3-BROMO-2-PICOLINE
• CAS NO: 186593-43-1
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.03718
• Product Categories: Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 186593-43-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 103.0 to 108.0 °C
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 123.9 °C
• Appearance: /
• Density: 1.593 g/cm³
• Vapor Pressure: 0.00359mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.53±0.20(Predicted)
• CAS DataBase Reference: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(186593-43-1)
• EPA Substance Registry System: 5-AMINO-3-BROMO-2-METHYLPYRIDINE(186593-43-1)

Safety Data

• Hazardous Substances Data: 186593-43-1(Hazardous Substances Data)

Usage

Description

5-AMINO-3-BROMO-2-METHYLPYRIDINE is a chemical compound characterized by the presence of an amino group, a bromine atom, and a methyl group attached to a pyridine ring. This versatile reactant is known for its potential applications in various synthetic preparations, particularly in the synthesis of amino acids.

Uses

Used in Pharmaceutical Industry:
5-AMINO-3-BROMO-2-METHYLPYRIDINE is used as a key reactant in the synthesis of amino acids, which are essential building blocks for proteins and play a crucial role in various biological processes. 5-AMINO-3-BROMO-2-METHYLPYRIDINE is particularly utilized in the asymmetric enzymic transamination of keto acids, a process that involves the use of axially chiral pyridoxamines as catalysts. This method allows for the production of enantiomerically pure amino acids, which are highly valuable in the development of chiral drugs with improved efficacy and reduced side effects.
Additionally, 5-AMINO-3-BROMO-2-METHYLPYRIDINE may also find applications in other industries, such as agrochemicals, where it can be used as an intermediate in the synthesis of various active ingredients, or in the development of new materials with unique properties. However, further research and development are required to fully explore and realize the potential applications of this compound in these fields.

InChI:InChI=1/C6H7BrN2/c1-4-6(7)2-5(8)3-9-4/h2-3H,8H2,1H3

Upstream product

• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 7439-89-6 iron 
• 1190862-72-6 5-bromo-6-methylnicotinic acid 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 15862-33-6 3-bromo-2-hydroxy-5-nitropyridine 
• 15862-36-9 2,3-dibromo-5-nitropyridine 
• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 

Downstream Products

• 1620056-30-5 2-(5-bromo-6-methylpyridin-3-yl)isoindoline-1,3-dione 
• 1620056-33-8 (S)-N-((S)-1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1620056-34-9 (S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate 
• 1620056-35-0 (S)-tert-butyl 1-(3-(3-carbamoyl-4-fluorophenyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate 
• 1620056-36-1 C₃₃H₂₉F₃N₄O₆ 
• 1620056-37-2 (S)-5-(2-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide hydrochloride 
• 1620055-62-0 5-(2-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide 
• 1620055-63-1 5-(5-amino-2-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-2-fluorobenzamide 
• 1620056-41-8 (S)-2-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-3-yl)isoindoline-1,3-dione hydrochloride 
• 1620056-52-1 (S)-tert-butyl (1-(5-amino-3-bromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate 
• 1620056-53-2 (S)-tert-butyl (1-(5-amino-3,6-dibromopyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate 
• 1620056-54-3 (S)-tert-butyl (1-(3,6-dibromo-5-(2,2,2-trifluoroacetamido)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate 
• 1620056-81-6 (S)-N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-2,5-dibromopyridin-3-yl)-2,2,2-trifluoroacetamide TFA salt 
• 1620056-55-4 N-(2,5-dibromo-6-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Enzyme-Inspired Axially Chiral Pyridoxamines Armed with a Cooperative Lateral Amine Chain for Enantioselective Biomimetic Transamination

Enzymatic transamination is catalyzed by pyridoxal/pyridoxamine, and it involves remarkable cooperative catalysis of a Lys residue in the transaminase. Inspired by transaminases, we developed a class of axially chiral pyridoxamines 11 bearing a lateral amine arm. The pyridoxamines exhibited high catalytic activity and excellent enantioselectivity in asymmetric transamination of α-keto acids, to give various α-amino acids in 67-99% yields with 83-94% ee's. The lateral amine arm likely participates in cooperative catalysis as the Lys residue does in biological transamination and has an important impact on the transamination in terms of activity and enantioselectivity.

Anti-tumor activity with acetylene derivatives

The present invention relates to an aromatic ring disubstituted acetylene derivative of formula I, a pharmaceutical composition comprising the compound, and a use of the compound and of the pharmaceutical composition in the treatment and/or prevention of tumors, where A, B, T, M, Ra, Rb, Rt, m, n, and p are as defined in the present document.