1589081-11-7

Basic information

• Product Name: 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile
• Synonyms: 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile
• CAS NO: 1589081-11-7
• Molecular Weight: 459.552
• Mol File: 1589081-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile(1589081-11-7)
• EPA Substance Registry System: 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile(1589081-11-7)

Safety Data

• Hazardous Substances Data: 1589081-11-7(Hazardous Substances Data)

Upstream product

• 2362-62-1 4-methylthiobenzamide 
• 35199-18-9 4-chloromethyl-2-(4-methyl-phenyl)-thiazole 
• 1589080-67-0 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-mercaptopyrimidine-5-carbonitrile 
• 120-57-0 piperonal 
• 104-85-8 para-methylbenzonitrile 

Relevant articles and documents

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.