35199-18-9

Basic information

• Product Name: 4-(CHLOROMETHYL)-2-(4-METHYLPHENYL)-1,3-THIAZOLE HYDROCHLORIDE
• Synonyms: 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole(SALTDATA: FREE)
• CAS NO: 35199-18-9
• Molecular Formula: C₁₁H₁₀ClNS
• Molecular Weight: 223.73
• Mol File: 35199-18-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 358.6°Cat760mmHg
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 5.2E-05mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 4-(CHLOROMETHYL)-2-(4-METHYLPHENYL)-1,3-THIAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-2-(4-METHYLPHENYL)-1,3-THIAZOLE HYDROCHLORIDE(35199-18-9)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-2-(4-METHYLPHENYL)-1,3-THIAZOLE HYDROCHLORIDE(35199-18-9)

Safety Data

• Hazardous Substances Data: 35199-18-9(Hazardous Substances Data)

Usage

General Description

"4-(Chloromethyl)-2-(4-methylphenyl)-1,3-thiazole hydrochloride" is a chemical compound with a molecular formula C11H10ClNS. It is a thiazole derivative with a chlorine-substituted methyl group and a 4-methylphenyl group attached to the thiazole ring. 4-(CHLOROMETHYL)-2-(4-METHYLPHENYL)-1,3-THIAZOLE HYDROCHLORIDE is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive molecules. Its unique structure and reactivity make it useful in the development of potential therapeutic agents for various medical conditions. Additionally, it may also have applications in chemical research and development as a versatile intermediate for the synthesis of other organic compounds.

InChI:InChI=1/C11H10ClNS/c1-8-2-4-9(5-3-8)11-13-10(6-12)7-14-11/h2-5,7H,6H2,1H3

Upstream product

• 2362-62-1 4-methylthiobenzamide 
• 534-07-6 1,3-Dichloroacetone 
• 104-85-8 para-methylbenzonitrile 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 36093-97-7 (2-p-tolylthiazol-4-yl)methanol 
• 52041-96-0 5-bromo-2-p-tolyl-thiazole-4-carboxylic acid 
• 17228-99-8 2-(p-tolyl)thiazole-4-carboxylic acid 
• 64953-96-4 1-(2-p-tolylthiazol-4-yl)ethanol 
• 55327-29-2 2-p-tolylthiazole-4-carbaldehyde 
• 1589081-11-7 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-p-tolylthiazol-4-yl)methylthio) pyrimidine-5-carbonitrile 
• 940830-05-7 piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone 
• 89152-41-0 4-(iodomethyl)-2-(p-tolyl)thiazole 

Relevant articles and documents

Design, synthesis, fungicidal activities and structure–activity relationship studies of (?)-borneol derivatives containing 2-aryl-thiazole scaffold

A series of (-)-borneol derivatives containing 2-aryl-thiazole scaffold were designed, synthesized, and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these novel compounds against Fusarium oxysporum, Magnaporthe grisea, Botrytis cinerea, and Penicillium digitatum were evaluated. The results indicated that (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl(Z)-4-oxo-4-(((2-phenylthiazol-4-yl)methyl)amino)but-2-enoate (6a) displayed potential fungicidal activities with broad spectrum. Especially, 6a exhibited an IC50 value of 48.5 mg/L against P. digitatum, which has higher fungicidal activity than commercial products hymexazol and amicarthiazol. Moreover, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl-4-oxo-4-(((2-phenylthiazol-4-yl)methyl)amino)butanoate (5a) possesses an IC50 value of 24.3 mg/L against B. cinerea, comparable to hymexazol and far superior to amicarthiazol. Furthermore, the superficial structure–activity relationship was discussed, which might be helpful for discovering novel fungicides.

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.

N-heteroarylmethylpyrimidinamine compound, preparation method and applications thereof

The invention discloses an N-heteroarylmethylpyrimidinamine compound represented by a formula (I), a preparation method and applications thereof, wherein R, R, R, R, R, X and n in the formula (1) are defined in the specification. According to the present invention, the compound represented by the formula (I) has insecticidal/mite killing and/or bactericidal biological activity, and particularly provides high activity against Homoptera pests such as aphids, planthoppers and the like.