55327-29-2

Basic information

• Product Name: 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE
• Synonyms: 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE
• CAS NO: 55327-29-2
• Molecular Formula: C₁₁H₉NOS
• Molecular Weight: 203.26
• Mol File: 55327-29-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 360.532°C at 760 mmHg
• Flash Point: 171.844°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.42±0.10(Predicted)
• CAS DataBase Reference: 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE(55327-29-2)
• EPA Substance Registry System: 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE(55327-29-2)

Safety Data

• Hazardous Substances Data: 55327-29-2(Hazardous Substances Data)

Usage

General Description

2-P-Tolyl-thiazole-4-carbaldehyde is an organic chemical compound with the molecular formula C11H9NOS. It is a yellow crystalline solid that is commonly used in the synthesis and production of various pharmaceuticals and agrochemicals. 2-P-TOLYL-THIAZOLE-4-CARBALDEHYDE has a thiazole ring with an aldehyde group and a para-tolyl substituent. It functions as a versatile building block in organic synthesis and has applications in the development of various medicinal and agricultural products. Additionally, it is used as a reagent in the laboratory for the preparation of a wide range of chemical compounds. Overall, 2-P-tolyl-thiazole-4-carbaldehyde plays an important role in the field of organic chemistry and has diverse applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C11H9NOS/c1-8-2-4-9(5-3-8)11-12-10(6-13)7-14-11/h2-7H,1H3

Upstream product

• 89152-41-0 4-(iodomethyl)-2-(p-tolyl)thiazole 
• 2362-62-1 4-methylthiobenzamide 
• 35199-18-9 4-chloromethyl-2-(4-methyl-phenyl)-thiazole 
• 104-85-8 para-methylbenzonitrile 
• 36093-97-7 (2-p-tolylthiazol-4-yl)methanol 
• 534-07-6 1,3-Dichloroacetone 
• 132089-32-8 2-(4'-methylphenyl)-4-carbethoxythiazole 

Downstream Products

• 21166-38-1 1-(2-p-tolyl-thiazol-4-yl)-ethanone 
• 138019-77-9 (Z)-1-(2-Hydroxy-phenyl)-3-(2-p-tolyl-thiazol-4-yl)-propenone 
• 116227-88-4 (Z)-1-Phenyl-3-(2-p-tolyl-thiazol-4-yl)-propenone 
• 108735-89-3 2-p-Tolyl-thiazole-4-carbaldehyde oxime 
• 174006-75-8 2-(p-tolyl)thiazole-4-carbonitrile 
• 174006-79-2 2-(p-tolyl)thiazole-4-carbothioamide 
• 116228-06-9 4-(2,5-Diphenyl-2H-pyrazol-3-yl)-2-p-tolyl-thiazole 
• 116227-96-4 4-(2,5-Diphenyl-3,4-dihydro-2H-pyrazol-3-yl)-2-p-tolyl-thiazole 
• 138019-87-1 3-Hydroxy-2-(2-p-tolyl-thiazol-4-yl)-chromen-4-one 
• 138019-82-6 Acetic acid 2-[(Z)-3-(2-p-tolyl-thiazol-4-yl)-acryloyl]-phenyl ester 
• 138019-92-8 Acetic acid 4-oxo-2-(2-p-tolyl-thiazol-4-yl)-4H-chromen-3-yl ester 
• 17228-99-8 2-(p-tolyl)thiazole-4-carboxylic acid 
• 64953-96-4 1-(2-p-tolylthiazol-4-yl)ethanol 
• 1585214-71-6 rac-2-(ethoxycarbonyl)-1-(2-p-tolylthiazol-4-yl)ethyl butanoate 

Relevant articles and documents

Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents

To search for potent antimycobacterial lead compounds, a new series of 3-substituted phenyl-2-(2-(substituted phenyl)thiazol-4-yl) thiazolidin-4-one (5a-t) derivatives have been synthesized by the condensation of 2-substituted phenyl thiazole-4-carbaldehy

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.

Synthesis, cytotoxicity assessment, and molecular docking of 4-substituted-2-p-tolylthiazole derivatives as probable c-Src and erb tyrosine kinase inhibitors

In the current project we focused on the synthesis of 4-Substituted-2-p- tolylthiazole derivatives. Cytotoxicity of synthesized compounds were evaluated against T47D breast cancer cell line and also all of the final compounds 3-7 were docked into the active site of c-Src and erb tyrosine kinases. Compound 4 was the most potent derivative in cytotoxicity assay (IC50 = 2.5 μg/mL) and it was also the most potent inhibitor of erb tyrosine kinase (Binding free energy: -10.18 kcal/mol).