940830-05-7

Basic information

• Product Name: piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone
• Synonyms: piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone
• CAS NO: 940830-05-7
• Molecular Weight: 286.398
• Mol File: 940830-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone(940830-05-7)
• EPA Substance Registry System: piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone(940830-05-7)

Safety Data

• Hazardous Substances Data: 940830-05-7(Hazardous Substances Data)

Upstream product

• 36093-97-7 (2-p-tolylthiazol-4-yl)methanol 
• 35199-18-9 4-chloromethyl-2-(4-methyl-phenyl)-thiazole 
• 104-85-8 para-methylbenzonitrile 
• 2362-62-1 4-methylthiobenzamide 
• 110-89-4 piperidine 
• 17228-99-8 2-(p-tolyl)thiazole-4-carboxylic acid 

Relevant articles and documents

Synthesis, cytotoxicity assessment, and molecular docking of 4-substituted-2-p-tolylthiazole derivatives as probable c-Src and erb tyrosine kinase inhibitors

In the current project we focused on the synthesis of 4-Substituted-2-p- tolylthiazole derivatives. Cytotoxicity of synthesized compounds were evaluated against T47D breast cancer cell line and also all of the final compounds 3-7 were docked into the active site of c-Src and erb tyrosine kinases. Compound 4 was the most potent derivative in cytotoxicity assay (IC50 = 2.5 μg/mL) and it was also the most potent inhibitor of erb tyrosine kinase (Binding free energy: -10.18 kcal/mol).